IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of 
the cortical interneuron subtype

Hayano, Yasufumi; Ishino, Yugo; Hyun, Jung Ho; Orozco, Carlos G.; Steinecke, André; Potts, Elizabeth; Oisi, Yasuhiro; Thomas, Connon I.; Guerrero-Given, Debbie; Kim, Eunjoon; Kwon, Hyung-Bae; Kamasawa, Naomi; Taniguchi, Hiroki

Lokale TagsFreigabegeschichteDetailsÜbersicht

IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype

Hayano, Y., Ishino, Y., Hyun, J. H., Orozco, C. G., Steinecke, A., Potts, E., et al. (2021). IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype. Science Advances, (29). Retrieved from https://advances.sciencemag.org/content/7/29/eabf1600.

Item is Freigegeben

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:

Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000C-DFD0-E Versions-Permalink: https://hdl.handle.net/21.11116/0000-000C-DFD1-D

Genre: Zeitschriftenartikel

Alternativer Titel : Science Advances

ausblenden:

Urheber:
Hayano, Yasufumi¹, Autor
Ishino, Yugo¹, Autor
Hyun, Jung Ho¹, Autor
Orozco, Carlos G.¹, Autor
Steinecke, André¹, Autor
Potts, Elizabeth¹, Autor
Oisi, Yasuhiro¹, Autor
Thomas, Connon I.¹, Autor
Guerrero-Given, Debbie¹, Autor
Kim, Eunjoon¹, Autor
Kwon, Hyung-Bae¹, Autor
Kamasawa, Naomi¹, Autor
Taniguchi, Hiroki¹, Autor

Affiliations:
1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288

Inhalt

einblenden:

ausblenden:

Schlagwörter: -

Zusammenfassung: The most prominent structural hallmark of the mammalian neocortical circuitry is the layer-based organization of specific cell types and synaptic inputs. Accordingly, cortical inhibitory interneurons (INs), which shape local network activity, exhibit subtype-specific laminar specificity of synaptic outputs. However, the underlying molecular mechanisms remain unknown. Here, we demonstrate that Immunoglobulin Superfamily member 11 (IgSF11) homophilic adhesion proteins are preferentially expressed in one of the most distinctive IN subtypes, namely, chandelier cells (ChCs) that specifically innervate axon initial segments of pyramidal neurons (PNs), and their synaptic laminar target. Loss-of-function experiments in either ChCs or postsynaptic cells revealed that IgSF11 is required for ChC synaptic development in the target layer. While overexpression of IgSF11 in ChCs enlarges ChC presynaptic boutons, expressing IgSF11 in nontarget layers induces ectopic ChC synapses. These findings provide evidence that synapse-promoting adhesion proteins, highly localized to synaptic partners, determine the layer-specific synaptic connectivity of the cortical IN subtype.
IgSF11 homophilic cell adhesion molecules regulate the synaptic laminar specificity of cortical chandelier cells.
IgSF11 homophilic cell adhesion molecules regulate the synaptic laminar specificity of cortical chandelier cells.