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  Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging profiles

Maleki Balajoo, S., Eickhoff, S. B., Masouleh, S. K., Plachti, A., Waite, L., Saberi, A., et al. (2023). Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging profiles. Alzheimer's and Dementia, 19(11), 4787-4804. doi:10.1002/alz.13056.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-EC80-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-F122-C
Genre: Journal Article

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 Creators:
Maleki Balajoo, Somayeh1, 2, Author
Eickhoff, Simon B.1, 2, Author
Masouleh, Shahrzad Kharabian1, 2, Author
Plachti, Anna1, 2, 3, Author
Waite, Laura2, Author
Saberi, Amin1, 2, 4, Author                 
Bahri, Mohamed Ali5, Author
Bastin, Christine5, 6, Author
Salmon, Eric5, 6, 7, Author
Hoffstaedter, Felix2, Author
Palomero‐Gallagher, Nicola8, 9, 10, Author
Genon, Sarah1, 2, 5, Author
Affiliations:
1Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
2Research Center Jülich, Germany, ou_persistent22              
3Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              
4Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
5GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Belgium, ou_persistent22              
6Psychology and Neuroscience of Cognition (PsyNCog), University of Liège, Belgium, ou_persistent22              
7Department of Neurology, University of Liège, Belgium, ou_persistent22              
8Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
9Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Germany, ou_persistent22              
10C. and O. Vogt Institute for Brain Research, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              

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Free keywords: Alzheimer's disease; Elderly; Hippocampal parcellation; Metabolic covariance; Networks
 Abstract: Introduction: Hippocampal local and network dysfunction is the hallmark of Alzheimer's disease (AD).

Methods: We characterized the spatial patterns of hippocampus differentiation based on brain co-metabolism in healthy elderly participants and demonstrated their relevance to study local metabolic changes and associated dysfunction in pathological aging.

Results: The hippocampus can be differentiated into anterior/posterior and dorsal cornu ammonis (CA)/ventral (subiculum) subregions. While anterior/posterior CA show co-metabolism with different regions of the subcortical limbic networks, the anterior/posterior subiculum are parts of cortical networks supporting object-centered memory and higher cognitive demands, respectively. Both networks show relationships with the spatial patterns of gene expression pertaining to cell energy metabolism and AD's process. Finally, while local metabolism is generally lower in posterior regions, the anterior-posterior imbalance is maximal in late mild cognitive impairment with the anterior subiculum being relatively preserved.

Discussion: Future studies should consider bidimensional hippocampal differentiation and in particular the posterior subicular region to better understand pathological aging.

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Language(s): eng - English
 Dates: 2023-02-282023-03-012023-04-042023-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/alz.13056
Other: epub 2023
PMID: 37014937
 Degree: -

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Project name : -
Grant ID : U01 AG024904; W81XWH-12-2-0012
Funding program : -
Funding organization : Alzheimer's Disease Neuroimaging Initiative (ADNI)
Project name : -
Grant ID : GE 2835/2–1; EI 816/4–1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : R01-MH074457
Funding program : -
Funding organization : National Institute of Mental Health (NIMH)
Project name : -
Grant ID : 945539; 826421
Funding program : -
Funding organization : Research and Innovation Programme
Project name : -
Grant ID : JLSMHB-2021-2027
Funding program : -
Funding organization : Helmholtz-Gemeinschaft
Project name : -
Grant ID : -
Funding program : -
Funding organization : Projekt DEAL

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Title: Alzheimer's and Dementia
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY, USA : Elsevier
Pages: - Volume / Issue: 19 (11) Sequence Number: - Start / End Page: 4787 - 4804 Identifier: ISSN: 1552-5260
CoNE: https://pure.mpg.de/cone/journals/resource/1552-5260