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  Diverging asymmetry of intrinsic functional organization in autism

Wan, B., Hong, S.-J., Bethlehem, R. A. I., Floris, D. L., Bernhardt, B. C., & Valk, S. L. (2023). Diverging asymmetry of intrinsic functional organization in autism. Molecular Psychiatry, 28(10), 4331-4341. doi:10.1038/s41380-023-02220-x.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-EC96-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-0FE8-C
Genre: Journal Article

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https://www.biorxiv.org/content/10.1101/2023.04.05.535683v1 (Preprint)
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 Creators:
Wan, Bin1, 2, 3, 4, Author                 
Hong, Seok-Jun5, Author
Bethlehem, Richard A. I.6, Author
Floris, Dorothea L.7, 8, Author
Bernhardt, Boris C.9, Author
Valk, Sofie L.1, 4, 10, Author                 
Affiliations:
1Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
2International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, South Korea, ou_persistent22              
6Department of Psychology, University of Cambridge, United Kingdom, ou_persistent22              
7Department of Psychology, University of Zurich, Switzerland, ou_persistent22              
8Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
9McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
10Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              

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Free keywords: Autism spectrum disorders; Neuroscience; Psychology
 Abstract: Autism is a neurodevelopmental condition involving atypical sensory-perceptual functions together with language and socio-cognitive deficits. Previous work has reported subtle alterations in the asymmetry of brain structure and reduced laterality of functional activation in individuals with autism relative to non-autistic individuals (NAI). However, whether functional asymmetries show altered intrinsic systematic organization in autism remains unclear. Here, we examined inter- and intra-hemispheric asymmetry of intrinsic functional gradients capturing connectome organization along three axes, stretching between sensory-default, somatomotor-visual, and default-multiple demand networks, to study system-level hemispheric imbalances in autism. We observed decreased leftward functional asymmetry of language network organization in individuals with autism, relative to NAI. Whereas language network asymmetry varied across age groups in NAI, this was not the case in autism, suggesting atypical functional laterality in autism may result from altered developmental trajectories. Finally, we observed that intra- but not inter-hemispheric features were predictive of the severity of autistic traits. Our findings illustrate how regional and patterned functional lateralization is altered in autism at the system level. Such differences may be rooted in atypical developmental trajectories of functional organization asymmetry in autism.

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Language(s): eng - English
 Dates: 2023-08-012023-04-062023-08-042023-08-162023-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41380-023-02220-x
Other: epub 2023
PMID: 37587246
 Degree: -

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Project name : -
Grant ID : NSERC Discovery-1304413
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Funding organization : National Science and Engineering Research Council of Canada (NSERC)
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Grant ID : FDN-154298; PJT-174995
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Funding organization : Canadian Institutes of Health Research (CIHR)
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Grant ID : NI17-039
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Funding organization : SickKids Foundation
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Funding organization : BrainCanada
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Funding organization : FRQ-S
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Funding organization : Tier-2 Canada Research Chairs program
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Funding organization : Helmholtz International BigBrain Analytics and Learning Laboratory (HIBALL)
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Funding organization : Helmholtz Association’s Initiative and Networking Fund and the Healthy Brains, Healthy Lives initiative at McGill University
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Funding organization : Max Planck Society
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Funding organization : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
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Funding organization : Graduate Academy Leipzig
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Funding organization : Projekt DEAL

Source 1

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Title: Molecular Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 28 (10) Sequence Number: - Start / End Page: 4331 - 4341 Identifier: ISSN: 1359-4184
CoNE: https://pure.mpg.de/cone/journals/resource/954925619131