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  Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers

Sugier, P.-E., Lucotte, E. H., Domenighetti, C. M., Law, M., Iles, M., Brown, K. D., Amos, C. J., McKay, J., Hung, R., Karimi, M., Bacq-Daian, D., Boland-Auge, A., Olaso, R., Deleuze, J.-f., Lesueur, F., Ostroumova, E., Kesminiene, A., de Vathaire, F., Guenel, P., Sreelatha, A. A. K., Schulte, C., Grover, S. R., May, P., Bobbili, D., Radivojkov-Blagojevic, M. B., Lichtner, P. G., Singleton, A., Hernandez, D. D., Edsall, C., Mellick, G., Zimprich, A., Pirker, W. E., Rogaeva, E., Lang, A., Koks, S., Taba, P., Lesage, S., Brice, A., Corvol, J.-C., Chartier-Harlin, M.-C., Mutez, E. B., Brockmann, K. M., Deutschlaender, A., Hadjigeorgiou, G., Dardiotis, E., Stefanis, L., Simitsi, A. M., Valente, E. M., Petrucci, S., Straniero, L., Zecchinelli, A., Pezzoli, G., Brighina, L., Ferrarese, C., Annesi, G., Quattrone, A., Gagliardi, M., Matsuo, H., Nakayama, A., Hattori, N., Nishioka, K., Chung, S. J., Kim, Y. J., Kolber, P. R., van de Warrenburg, B. P. C., Bloem, B., Aasly, J., Toft, M., Pihlstrom, L. J., Guedes, L. C., Ferreira, J., Bardien, S., Carr, J., Tolosa, E., Ezquerra, M., Pastor, P., Diez-Fairen, M., Wirdefeldt, K., Pedersen, N. C., Ran, C., Belin, A., Puschmann, A. E., Roedstroem, E. Y. E., Clarke, C., Morrison, K., Tan, M. F., Krainc, D. J., Burbulla, L., Farrer, M., Kruger, R., Gasser, T., Sharma, M., Truong, T., & Elbaz, A. (2023). Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers. MOVEMENT DISORDERS, 38(4), 604-615. doi:10.1002/mds.29337.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000D-07C7-B 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-E847-E
資料種別: 学術論文

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 作成者:
Sugier, Pierre-Emmanuel, 著者
Lucotte, Elise H., 著者
Domenighetti, Cloe M., 著者
Law, Matthew, 著者
Iles, Mark, 著者
Brown, Kevin D., 著者
Amos, Christopher J., 著者
McKay, James, 著者
Hung, Rayjean, 著者
Karimi, Mojgan, 著者
Bacq-Daian, Delphine, 著者
Boland-Auge, Anne, 著者
Olaso, Robert, 著者
Deleuze, Jean-francois, 著者
Lesueur, Fabienne, 著者
Ostroumova, Evgenia, 著者
Kesminiene, Ausrele, 著者
de Vathaire, Florent, 著者
Guenel, Pascal, 著者
Sreelatha, Ashwin Ashok Kumar, 著者
Schulte, Claudia, 著者Grover, Sandeep R., 著者May, Patrick, 著者Bobbili, Dheeraj, 著者Radivojkov-Blagojevic, Milena B., 著者Lichtner, Peter G., 著者Singleton, Andrew, 著者Hernandez, Dena D., 著者Edsall, Connor, 著者Mellick, George, 著者Zimprich, Alexander, 著者Pirker, Walter E., 著者Rogaeva, Ekaterina, 著者Lang, Anthony, 著者Koks, Sulev, 著者Taba, Pille, 著者Lesage, Suzanne, 著者Brice, Alexis, 著者Corvol, Jean-Christophe, 著者Chartier-Harlin, Marie-Christine, 著者Mutez, Eugenie B., 著者Brockmann, Kathrin M., 著者Deutschlaender, Angela1, 著者           Hadjigeorgiou, Georges, 著者Dardiotis, Efthimios, 著者Stefanis, Leonidas, 著者Simitsi, Athina Maria, 著者Valente, Enza Maria, 著者Petrucci, Simona, 著者Straniero, Letizia, 著者Zecchinelli, Anna, 著者Pezzoli, Gianni, 著者Brighina, Laura, 著者Ferrarese, Carlo, 著者Annesi, Grazia, 著者Quattrone, Andrea, 著者Gagliardi, Monica, 著者Matsuo, Hirotaka, 著者Nakayama, Akiyoshi, 著者Hattori, Nobutaka, 著者Nishioka, Kenya, 著者Chung, Sun Ju, 著者Kim, Yun Joong, 著者Kolber, Pierre R., 著者van de Warrenburg, Bart P. C., 著者Bloem, Bastiaan, 著者Aasly, Jan, 著者Toft, Mathias, 著者Pihlstrom, Lasse J., 著者Guedes, Leonor Correia, 著者Ferreira, Joaquim, 著者Bardien, Soraya, 著者Carr, Jonathan, 著者Tolosa, Eduardo, 著者Ezquerra, Mario, 著者Pastor, Pau, 著者Diez-Fairen, Monica, 著者Wirdefeldt, Karin, 著者Pedersen, Nancy C., 著者Ran, Caroline, 著者Belin, Andrea, 著者Puschmann, Andreas E., 著者Roedstroem, Emil Ygland E., 著者Clarke, Carl, 著者Morrison, Karen, 著者Tan, Manuela F., 著者Krainc, Dimitri J., 著者Burbulla, Lena, 著者Farrer, Matt, 著者Kruger, Rejko, 著者Gasser, Thomas, 著者Sharma, Manu, 著者Truong, Therese, 著者Elbaz, Alexis, 著者 全て表示
所属:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

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 要旨: BackgroundEpidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. ObjectiveWe used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors. MethodsWe used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses. ResultsWe confirmed a previously reported positive genetic correlation of PD with melanoma (G(corr) = 0.16 [0.04; 0.28]) and reported an additional significant positive correlation of PD with prostate cancer (G(corr) = 0.11 [0.03; 0.19]). There was a significant inverse association between the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89 [0.84; 0.94]). Conversely, the PRS of PD was positively associated with breast cancer (OR = 1.08 [1.06; 1.10]) and inversely associated with ovarian cancer (OR = 0.95 [0.91; 0.99]). The association between PD and ovarian cancer was mostly driven by rs183211 located in an intron of the NSF gene (17q21.31). ConclusionsWe show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers. (c) 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

資料詳細

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 日付: 20232023-08
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
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 識別子（DOI, ISBNなど）: ISI: 000951688400001
DOI: 10.1002/mds.29337
 学位: -

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出版物 1

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出版物名: MOVEMENT DISORDERS
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: -
ページ: - 巻号: 38 (4) 通巻号: - 開始・終了ページ: 604 - 615 識別子（ISBN, ISSN, DOIなど）: ISSN: 0885-3185