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  Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain

Trofimova, O., Latypova, A., DiDomenicantonio, G., Lutti, A., de Lange, A.-M.-G., Kliegel, M., et al. (2023). Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain. Communications Biology, 6(1): 392. doi:10.1038/s42003-023-04741-1.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-06CF-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-95AF-4
Genre: Journal Article

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 Creators:
Trofimova, Olga1, 2, 3, Author
Latypova, Adeliya1, Author
DiDomenicantonio, Giulia1, Author
Lutti, Antoine1, Author
de Lange, Ann-Marie G.1, 4, 5, Author
Kliegel, Matthias6, Author
Stringhini, Silvia7, 8, 9, Author
Marques-Vidal, Pedro10, Author
Vaucher, Julien10, Author
Vollenweider, Peter10, Author
Strippoli, Marie-Pierre F.11, Author
Preisig, Martin11, Author
Kherif, Ferath1, Author
Draganski, Bogdan1, 12, Author           
Affiliations:
1Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Department of Computational Biology, University of Lausanne, Switzerland, ou_persistent22              
3Swiss Institute of Bioinformatics, University of Lausanne, Switzerland, ou_persistent22              
4Department of Psychology, University of Oslo, Norway, ou_persistent22              
5Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
6Department of Psychology, University of Geneva, Switzerland, ou_persistent22              
7Center for Primary Care and Public Health, University of Lausanne, Switzerland, ou_persistent22              
8Institute of Social and Preventive Medicine (IUMSP), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
9Unit of Population Epidemiology, Division of Primary Care, University Hospital of Geneva, Switzerland, ou_persistent22              
10Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
11Center for Psychiatric Epidemiology and Psychopathology, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
12Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Biophysical models; Brain; Hypertension; Neural ageing; Risk factors
 Abstract: Our knowledge of the mechanisms underlying the vulnerability of the brain's white matter microstructure to cardiovascular risk factors (CVRFs) is still limited. We used a quantitative magnetic resonance imaging (MRI) protocol in a single centre setting to investigate the cross-sectional association between CVRFs and brain tissue properties of white matter tracts in a large community-dwelling cohort (n = 1104, age range 46-87 years). Arterial hypertension was associated with lower myelin and axonal density MRI indices, paralleled by higher extracellular water content. Obesity showed similar associations, though with myelin difference only in male participants. Associations between CVRFs and white matter microstructure were observed predominantly in limbic and prefrontal tracts. Additional genetic, lifestyle and psychiatric factors did not modulate these results, but moderate-to-vigorous physical activity was linked to higher myelin content independently of CVRFs. Our findings complement previously described CVRF-related changes in brain water diffusion properties pointing towards myelin loss and neuroinflammation rather than neurodegeneration.

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Language(s): eng - English
 Dates: 2022-10-242023-03-212023-04-102023-04-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s42003-023-04741-1
PMID: 37037939
PMC: PMC10086032
 Degree: -

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Project name : -
Grant ID : 320030_184784; 32003B_212466; 324730_192755; CRSII5-3_209510; PZ00P3_193658; 3200B0–105993; 3200B0-118308; 33CSCO-122661; 33CS30-139468; 33CS30-148401; 33CS30_177535; 3247730_204523
Funding program : -
Funding organization : Swiss National Science Foundation (SNSF)
Project name : iSEE project
Grant ID : 32NE30_198552
Funding program : -
Funding organization : ERA_NET
Project name : SACR project
Grant ID : -
Funding program : -
Funding organization : Swiss Personalized Health Network (SPHN)
Project name : -
Grant ID : -
Funding program : CLIMACT starting grant
Funding organization : UNIL-EPFL
Project name : -
Grant ID : -
Funding program : -
Funding organization : Leenaards Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Roger De Spoelberch and Partridge Foundations
Project name : -
Grant ID : -
Funding program : -
Funding organization : GlaxoSmithKline
Project name : -
Grant ID : -
Funding program : -
Funding organization : Faculty of Biology and Medicine of Lausanne

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Title: Communications Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Springer Nature
Pages: - Volume / Issue: 6 (1) Sequence Number: 392 Start / End Page: - Identifier: ISSN: 2399-3642
CoNE: https://pure.mpg.de/cone/journals/resource/2399-3642