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  Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions

Schindler, D., Dai, J., & Cai, Y. (2018). Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions. CURRENT OPINION IN CHEMICAL BIOLOGY, 46, 56-62. doi:10.1016/j.cbpa.2018.04.002.

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 Creators:
Schindler, Daniel1, Author                 
Dai, Junbiao2, Author
Cai, Yizhi2, Author
Affiliations:
1Manchester Institute of Biotechnology, University of Manchester, UK, ou_persistent22              
2external, ou_persistent22              

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 Abstract: Since the first synthetic gene was synthesized in 1970s, the efficiency
and the capacity of made-to-order DNA sequence synthesis has increased
by several orders of magnitude. Advances in DNA synthesis and assembly
over the past years has resulted in a steep drop in price for custom
made DNA. Similar effects were observed in DNA sequencing technologies
which underpin DNA-reading projects. Today, synthetic DNA sequences with
more than 10 000 bps and turnaround times of a few weeks are
commercially available. This enables researchers to perform large-scale
projects to write synthetic chromosomes and characterize their
functionalities in vivo. Synthetic genomics opens up new paradigms to
study the genome fundamentals and engineer novel biological functions.

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 Dates: 2018-10
 Publication Status: Issued
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Title: CURRENT OPINION IN CHEMICAL BIOLOGY
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 46 Sequence Number: - Start / End Page: 56 - 62 Identifier: ISSN: 1367-5931