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  Macroscale thalamic functional organization disturbances and underlying core cytoarchitecture in early-onset schizophrenia

Fan, Y.-S., Xu, Y., Bayrak, S., Shine, J. M., Wan, B., Li, H., et al. (2023). Macroscale thalamic functional organization disturbances and underlying core cytoarchitecture in early-onset schizophrenia. Schizophrenia Bulletin, 49(5), 1375-1386. doi:10.1093/schbul/sbad048.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000D-09C1-F Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-4B27-2
Genre: Zeitschriftenartikel

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externe Referenz:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483446/ (beliebiger Volltext)
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OA-Status:
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 Urheber:
Fan, Yun-Shuang1, 2, Autor
Xu, Yong3, Autor
Bayrak, Seyma2, Autor                 
Shine, James M.4, Autor
Wan, Bin2, 5, 6, Autor           
Li, Haoru1, Autor
Li, Liang1, 7, Autor
Yang, Siqi1, Autor
Meng, Yao1, Autor
Valk, Sofie L.2, 5, Autor                 
Chen, Huafu1, 8, Autor
Affiliations:
1School of Life Science & Technology, University of Electronic Science and Technology of China, Chengdu, China, ou_persistent22              
2Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
3Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China, ou_persistent22              
4Brain and Mind Centre, University of Sydney, Australia, ou_persistent22              
5Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
6International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
7Academy for Advanced Interdisciplinary Studies, Peking University, China, ou_persistent22              
8MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, China, ou_persistent22              

Inhalt

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Schlagwörter: Cytoarchitectural; Early-onset schizophrenia; Functional hierarchy; Genetic; Thalamus
 Zusammenfassung: Background and hypothesis: Schizophrenia is a polygenetic mental disorder with heterogeneous positive and negative symptom constellations, and is associated with abnormal cortical connectivity. The thalamus has a coordinative role in cortical function and is key to the development of the cerebral cortex. Conversely, altered functional organization of the thalamus might relate to overarching cortical disruptions in schizophrenia, anchored in development.

Study design: Here, we contrasted resting-state fMRI in 86 antipsychotic-naive first-episode early-onset schizophrenia (EOS) patients and 91 typically developing controls to study whether macroscale thalamic organization is altered in EOS. Employing dimensional reduction techniques on thalamocortical functional connectome (FC), we derived lateral-medial and anterior-posterior thalamic functional axes.

Study results: We observed increased segregation of macroscale thalamic functional organization in EOS patients, which was related to altered thalamocortical interactions both in unimodal and transmodal networks. Using an ex vivo approximation of core-matrix cell distribution, we found that core cells particularly underlie the macroscale abnormalities in EOS patients. Moreover, the disruptions were associated with schizophrenia-related gene expression maps. Behavioral and disorder decoding analyses indicated that the macroscale hierarchy disturbances might perturb both perceptual and abstract cognitive functions and contribute to negative syndromes in patients.

Conclusions: These findings provide mechanistic evidence for disrupted thalamocortical system in schizophrenia, suggesting a unitary pathophysiological framework.

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Sprache(n): eng - English
 Datum: 2023-04-202023-09-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1093/schbul/sbad048
PMC: PMC10483446
PMID: 37078906
 Art des Abschluß: -

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Projektinformation

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Projektname : -
Grant ID : 82121003; 62036003; 62073058; 62173070
Förderprogramm : -
Förderorganisation : National Natural Science Foundation of China (NSFC)
Projektname : -
Grant ID : ZYYCXTD-D-202003
Förderprogramm : Innovation Team and Talents Cultivation Program
Förderorganisation : National Administration of Traditional Chinese Medicine
Projektname : Helmholtz International Lab
Grant ID : InterLabs-0015
Förderprogramm : -
Förderorganisation : Helmholtz Association
Projektname : Healthy Brains, Healthy Lives initiative at McGill University
Grant ID : -
Förderprogramm : -
Förderorganisation : Canada First Research Excellence Fund (CFREF)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Helmholtz International BigBrain Analytics and Learning Laboratory (HIBALL)

Quelle 1

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Titel: Schizophrenia Bulletin
  Andere : Schizophr. Bull.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Rockville, MD : U.S. Dept. of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration
Seiten: - Band / Heft: 49 (5) Artikelnummer: - Start- / Endseite: 1375 - 1386 Identifikator: ISSN: 0586-7614
CoNE: https://pure.mpg.de/cone/journals/resource/954925532975