English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. Item Summary / 
  2. View item

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Macroscale thalamic functional organization disturbances and underlying core cytoarchitecture in early-onset schizophrenia

Fan, Y.-S., Xu, Y., Bayrak, S., Shine, J. M., Wan, B., Li, H., et al. (2023). Macroscale thalamic functional organization disturbances and underlying core cytoarchitecture in early-onset schizophrenia. Schizophrenia Bulletin, 49(5), 1375-1386. doi:10.1093/schbul/sbad048.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000D-09C1-F Version Permalink: https://hdl.handle.net/21.11116/0000-000F-4B27-2
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483446/ (Any fulltext)
Description:
-
OA-Status:
Miscellaneous

Creators

show
hide
 Creators:
Fan, Yun-Shuang1, 2, Author
Xu, Yong3, Author
Bayrak, Seyma2, Author                 
Shine, James M.4, Author
Wan, Bin2, 5, 6, Author           
Li, Haoru1, Author
Li, Liang1, 7, Author
Yang, Siqi1, Author
Meng, Yao1, Author
Valk, Sofie L.2, 5, Author                 
Chen, Huafu1, 8, Author
Affiliations:
1School of Life Science & Technology, University of Electronic Science and Technology of China, Chengdu, China, ou_persistent22              
2Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
3Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China, ou_persistent22              
4Brain and Mind Centre, University of Sydney, Australia, ou_persistent22              
5Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
6International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
7Academy for Advanced Interdisciplinary Studies, Peking University, China, ou_persistent22              
8MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, China, ou_persistent22              

Content

show
hide
Free keywords: Cytoarchitectural; Early-onset schizophrenia; Functional hierarchy; Genetic; Thalamus
 Abstract: Background and hypothesis: Schizophrenia is a polygenetic mental disorder with heterogeneous positive and negative symptom constellations, and is associated with abnormal cortical connectivity. The thalamus has a coordinative role in cortical function and is key to the development of the cerebral cortex. Conversely, altered functional organization of the thalamus might relate to overarching cortical disruptions in schizophrenia, anchored in development.

Study design: Here, we contrasted resting-state fMRI in 86 antipsychotic-naive first-episode early-onset schizophrenia (EOS) patients and 91 typically developing controls to study whether macroscale thalamic organization is altered in EOS. Employing dimensional reduction techniques on thalamocortical functional connectome (FC), we derived lateral-medial and anterior-posterior thalamic functional axes.

Study results: We observed increased segregation of macroscale thalamic functional organization in EOS patients, which was related to altered thalamocortical interactions both in unimodal and transmodal networks. Using an ex vivo approximation of core-matrix cell distribution, we found that core cells particularly underlie the macroscale abnormalities in EOS patients. Moreover, the disruptions were associated with schizophrenia-related gene expression maps. Behavioral and disorder decoding analyses indicated that the macroscale hierarchy disturbances might perturb both perceptual and abstract cognitive functions and contribute to negative syndromes in patients.

Conclusions: These findings provide mechanistic evidence for disrupted thalamocortical system in schizophrenia, suggesting a unitary pathophysiological framework.

Details

show
hide
Language(s): eng - English
 Dates: 2023-04-202023-09-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/schbul/sbad048
PMC: PMC10483446
PMID: 37078906
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : 82121003; 62036003; 62073058; 62173070
Funding program : -
Funding organization : National Natural Science Foundation of China (NSFC)
Project name : -
Grant ID : ZYYCXTD-D-202003
Funding program : Innovation Team and Talents Cultivation Program
Funding organization : National Administration of Traditional Chinese Medicine
Project name : Helmholtz International Lab
Grant ID : InterLabs-0015
Funding program : -
Funding organization : Helmholtz Association
Project name : Healthy Brains, Healthy Lives initiative at McGill University
Grant ID : -
Funding program : -
Funding organization : Canada First Research Excellence Fund (CFREF)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Helmholtz International BigBrain Analytics and Learning Laboratory (HIBALL)

Source 1

show
hide
Title: Schizophrenia Bulletin
  Other : Schizophr. Bull.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Rockville, MD : U.S. Dept. of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration
Pages: - Volume / Issue: 49 (5) Sequence Number: - Start / End Page: 1375 - 1386 Identifier: ISSN: 0586-7614
CoNE: https://pure.mpg.de/cone/journals/resource/954925532975