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  Disrupted resting-sate brain network dynamics in children born extremely preterm

Padilla, N., Escrichs, A., del Agua, E., Kringelbach, M., Donaire, A., Deco, G., et al. (2023). Disrupted resting-sate brain network dynamics in children born extremely preterm. Cerebral Cortex, 33(13), 8101-8109. doi:10.1093/cercor/bhad101.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-0A1B-B Version Permalink: https://hdl.handle.net/21.11116/0000-000F-5EE0-B
Genre: Journal Article

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 Creators:
Padilla, Nelly1, Author
Escrichs, Anira2, Author
del Agua, Elvira2, Author
Kringelbach, Morten3, 4, Author
Donaire, Antonio5, 6, Author
Deco, Gustavo2, 7, 8, 9, Author           
Åden, Ulrika1, 10, 11, Author
Affiliations:
1Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
2Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department of Psychiatry, Warneford Hospital, University of Oxford, United Kingdom, ou_persistent22              
4Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
5Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ou_persistent22              
6Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain, ou_persistent22              
7School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
8Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
9Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
10Department of Neonatology, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
11Department of Biomedical and Clinical Sciences, Linköping University, Sweden, ou_persistent22              

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Free keywords: Brain development; Brain network dynamic; Cognitive neurodevelopment; Extreme prematurity
 Abstract: The developing brain has to adapt to environmental and intrinsic insults after extremely preterm (EPT) birth. Ongoing maturational processes maximize their fit to the environment and this can provide a substrate for neurodevelopmental failures. Resting-state functional magnetic resonance imaging was used to scan 33 children born EPT, at < 27 weeks of gestational age, and 26 full-term controls at 10 years of age. We studied the capability of a brain area to propagate neural information (intrinsic ignition) and its variability across time (node-metastability). This framework was computed for the dorsal attention network (DAN), frontoparietal, default-mode network (DMN), and the salience, limbic, visual, and somatosensory networks. The EPT group showed reduced intrinsic ignition in the DMN and DAN, compared with the controls, and reduced node-metastability in the DMN, DAN, and salience networks. Intrinsic ignition and node-metastability values correlated with cognitive performance at 12 years of age in both groups, but only survived in the term group after adjustment. Preterm birth disturbed the signatures of functional brain organization at rest in 3 core high-order networks: DMN, salience, and DAN. Identifying vulnerable resting-state networks after EPT birth may lead to interventions that aim to rebalance brain function.

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Language(s): eng - English
 Dates: 2023-02-192022-08-312023-02-202023-04-202023-06-20
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhad101
PMID: 37083266
 Degree: -

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Project name : -
Grant ID : 523-2011-3981; 2017-03043
Funding program : -
Funding organization : Swedish Medical Research Council
Project name : -
Grant ID : ALF SLL 20170243
Funding program : regional agreement on medical training and clinical research
Funding organization : Stockholm County Council and the Karolinska Institutet
Project name : Seventh Framework Project
Grant ID : 223767
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : -
Funding program : -
Funding organization : Swedish Order of Freemasons in Stockholm
Project name : -
Grant ID : -
Funding program : -
Funding organization : Swedish Medical Society
Project name : -
Grant ID : FO2017-0131
Funding program : -
Funding organization : Swedish Brain Foundation
Project name : Human Brain Project (HBP)
Grant ID : 945539
Funding program : Horizon 2020
Funding organization : European Union

Source 1

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Title: Cerebral Cortex
  Abbreviation : 1047-3211
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 : Oxford University Press
Pages: - Volume / Issue: 33 (13) Sequence Number: - Start / End Page: 8101 - 8109 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/1047-3211