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  Identification of innate immunity elicitors using molecular signatures of natural selection

McCann, H., Nahal, H., Thakur, S., & Guttman, D. (2012). Identification of innate immunity elicitors using molecular signatures of natural selection. Proceedings of the National Academy of Sciences of the United States of America, 109(11), 4215-4220. doi:10.1073/pnas.1113893109.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000D-0CE8-1 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-0CE9-0
資料種別: 学術論文

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 作成者:
McCann, HC1, 著者                 
Nahal, H, 著者
Thakur, S, 著者
Guttman, DS, 著者
所属:
1External Organizations, ou_persistent22              

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 要旨: The innate immune system is an ancient and broad-spectrum defense system found in all eukaryotes. The detection of microbial elicitors results in the up-regulation of defense-related genes and the elicitation of inflammatory and apoptotic responses. These innate immune responses are the front-line barrier against disease because they collectively suppress the growth of the vast majority of invading microbes. Despite their critical role, we know remarkably little about the diversity of immune elicitors. To address this paucity, we reasoned that hosts are more likely to evolve recognition to "core" pathogen proteins under strong negative selection for the maintenance of essential cellular functions, whereas repeated exposure to host-defense responses will impose strong positive selective pressure for elicitor diversification to avoid host recognition. Therefore, we hypothesized that novel bacterial elicitors can be identified through these opposing forces of natural selection. We tested this hypothesis by examining the genomes of six bacterial phytopathogens and identifying 56 candidate elicitors that have an excess of positively selected residues in a background of strong negative selection. We show that these positively selected residues are atypically clustered, similar to patterns seen in the few well-characterized elicitors. We then validated selected candidate elicitors by showing that they induce Arabidopsis thaliana innate immunity in functional (virulence suppression) and cellular (callose deposition) assays. These finding provide targets for the study of host-pathogen interactions and applied research into alternative antimicrobial treatments.

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 日付: 2012-03
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): DOI: 10.1073/pnas.1113893109
PMID: 22323605
 学位: -

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出版物 1

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出版物名: Proceedings of the National Academy of Sciences of the United States of America
  その他 : PNAS
  その他 : Proceedings of the National Academy of Sciences of the USA
  省略形 : Proc. Natl. Acad. Sci. U. S. A.
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Washington, D.C. : National Academy of Sciences
ページ: - 巻号: 109 (11) 通巻号: - 開始・終了ページ: 4215 - 4220 識別子(ISBN, ISSN, DOIなど): ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230