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  Reliability of resting-state functional connectivity in the human spinal cord: Assessing the impact of distinct noise sources

Kaptan, M., Horn, U., Vannesjo, S. J., Mildner, T., Weiskopf, N., Finsterbusch, J., Brooks, J. C., & Eippert, F. (2023). Reliability of resting-state functional connectivity in the human spinal cord: Assessing the impact of distinct noise sources. NeuroImage, 275:. doi:10.1016/j.neuroimage.2023.120152.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000D-0F07-C 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000F-5FF5-3
資料種別: 学術論文

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https://github.com/eippertlab/restingstate-reliability-spinalcord (Code)
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作成者

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 作成者:
Kaptan, Merve1, 著者                 
Horn, Ulrike1, 著者
Vannesjo, S. Johanna2, 著者
Mildner, Toralf3, 著者           
Weiskopf, Nikolaus4, 5, 著者                 
Finsterbusch, Jürgen6, 著者
Brooks, Jonathan C.W.7, 著者
Eippert, Falk1, 著者
所属:
1Max Planck Research Group Pain Perception, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2497695              
2Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
3Methods and Development Group Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
6Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
7School of Psychology, University of East Anglia Wellcome Wolfson Brain Imaging Centre (UWWBIC), Norwich, United Kingdom, ou_persistent22              

内容説明

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キーワード: -
 要旨: The investigation of spontaneous fluctuations of the blood-oxygen-level-dependent (BOLD) signal has recently been extended from the brain to the spinal cord, where it has stimulated interest from a clinical perspective. A number of resting-state functional magnetic resonance imaging (fMRI) studies have demonstrated robust functional connectivity between the time series of BOLD fluctuations in bilateral dorsal horns and between those in bilateral ventral horns, in line with the functional neuroanatomy of the spinal cord. A necessary step prior to extension to clinical studies is assessing the reliability of such resting-state signals, which we aimed to do here in a group of 45 healthy young adults at the clinically prevalent field strength of 3T. When investigating connectivity in the entire cervical spinal cord, we observed fair to good reliability for dorsal-dorsal and ventral-ventral connectivity, whereas reliability was poor for within- and between-hemicord dorsal-ventral connectivity. Considering how prone spinal cord fMRI is to noise, we extensively investigated the impact of distinct noise sources and made two crucial observations: removal of physiological noise led to a reduction in functional connectivity strength and reliability – due to the removal of stable and participant-specific noise patterns – whereas removal of thermal noise considerably increased the detectability of functional connectivity without a clear influence on reliability. Finally, we also assessed connectivity within spinal cord segments and observed that while the pattern of connectivity was similar to that of whole cervical cord, reliability at the level of single segments was consistently poor. Taken together, our results demonstrate the presence of reliable resting-state functional connectivity in the human spinal cord even after thoroughly accounting for physiological and thermal noise, but at the same time urge caution if focal changes in connectivity (e.g. due to segmental lesions) are to be studied, especially in a longitudinal manner.

資料詳細

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言語: eng - English
 日付: 2023-04-202023-01-222023-05-012023-05-022023-07-15
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1016/j.neuroimage.2023.120152
その他: epub 2023
PMID: 37142169
 学位: -

関連イベント

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Project information

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Project name : -
Grant ID : MR/N026969/1
Funding program : -
Funding organization : UK Medical Research Council (MRC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : 758974; 681094
Funding program : Horizon 2020
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : 616905
Funding program : European Union's Seventh Framework Programme (FP7/2007-2013)
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : 01EW1711A & B
Funding program : ERA-NET NEURON
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

出版物 1

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出版物名: NeuroImage
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Orlando, FL : Academic Press
ページ: - 巻号: 275 通巻号: 120152 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166