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  De novo phytosterol synthesis in animals

Michellod, D., Bien, T., Birgel, D., Violette, M., Kleiner, M., Fearn, S., et al. (2023). De novo phytosterol synthesis in animals. Science. doi:10.1126/science.add7830.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-1203-B Version Permalink: https://hdl.handle.net/21.11116/0000-000D-123F-9
Genre: Journal Article

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 Creators:
Michellod, Dolma1, Author           
Bien, Tanja2, Author
Birgel, Daniel2, Author
Violette, Marlene2, Author
Kleiner, Manuel2, Author
Fearn, Sarah2, Author
Zeidler, Caroline1, Author           
Gruber-Vodicka, Harald R.1, Author           
Dubilier, Nicole1, Author           
Liebeke, Manuel1, Author           
Affiliations:
1Department of Symbiosis, Max Planck Institute for Marine Microbiology, Max Planck Society, ou_2481699              
2external, 2, ou_persistent22              

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 Abstract: Sterols are vital for nearly all eukaryotes. Their distribution differs in plants and animals, with phytosterols commonly found in plants whereas most animals are dominated by cholesterol. We show that sitosterol, a common sterol of plants, is the most abundant sterol in gutless marine annelids. Using multiomics, metabolite imaging, heterologous gene expression, and enzyme assays, we show that these animals synthesize sitosterol de novo using a noncanonical C-24 sterol methyltransferase (C24-SMT). This enzyme is essential for sitosterol synthesis in plants, but not known from most bilaterian animals. Our phylogenetic analyses revealed that C24-SMTs are present in representatives of at least five animal phyla, indicating that the synthesis of sterols common to plants is more widespread in animals than currently known.

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Language(s): eng - English
 Dates: 2023-05-04
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/science.add7830
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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1