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  C1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease: A multi-cohort proteomics and immuno-assay validation study

Chatterjee, M., Özdemir, S., Kunadt, M., Koel-Simmelink, M., Boiten, W., Piepkorn, L., et al. (2023). C1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease: A multi-cohort proteomics and immuno-assay validation study. Alzheimer's & Dementia, 19(11), 4828-4840. doi:10.1002/alz.13066.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-40E8-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-2BE0-5
Genre: Journal Article

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Alzheimer s Dementia - 2023 - Chatterjee.pdf (Publisher version), 2MB
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https://hdl.handle.net/21.11116/0000-000D-40EA-3
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Alzheimer s Dementia - 2023 - Chatterjee.pdf
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 Creators:
Chatterjee, Madhurima, Author
Özdemir, Selcuk, Author
Kunadt, Marcel, Author
Koel-Simmelink, Marleen, Author
Boiten, Walter, Author
Piepkorn, Lars1, Author           
Pham, Thang V., Author
Chiasserini, Davide, Author
Piersma, Sander R., Author
Knol, Jaco C., Author
Möbius, Wiebke2, Author           
Mollenhauer, Brit, Author
van der Flier, Wiesje M., Author
Jimenez, Connie R., Author
Teunissen, Charlotte E., Author
Jahn, Olaf1, Author           
Schneider, Anja, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350300              
2Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350301              

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 Abstract: Introduction:
Extracellular vesicles (EVs) may propagate and modulate Alzheimer's disease (AD) pathology. We aimed to comprehensively characterize the proteome of cerebrospinal fluid (CSF) EVs to identify proteins and pathways altered in AD.

Methods:
CSF EVs were isolated by ultracentrifugation (Cohort 1) or Vn96 peptide (Cohort 2) from non-neurodegenerative controls (n = 15, 16) and AD patients (n = 22, 20, respectively). EVs were subjected to untargeted quantitative mass spectrometry-based proteomics. Results were validated by enzyme-linked immunosorbent assay (ELISA) in Cohorts 3 and 4, consisting of controls (n = 16, n = 43, (Cohort3, Cohort4)), and patients with AD (n = 24, n = 100).

Results:
We found > 30 differentially expressed proteins in AD CSF EVs involved in immune-regulation. Increase of C1q levels in AD compared to non-demented controls was validated by ELISA (∼ 1.5 fold, p (Cohort 3) = 0.03, p (Cohort 4) = 0.005).

Discussion:
EVs may be utilized as a potential biomarker and may play a so far unprecedented role in immune-regulation in AD.

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Language(s): eng - English
 Dates: 2023-04-062023-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/alz.13066
 Degree: -

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Title: Alzheimer's & Dementia
  Other : Alzheimer's and Dementia
Source Genre: Journal
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Publ. Info: Hoboken, New Jersey, USA : Wiley
Pages: - Volume / Issue: 19 (11) Sequence Number: - Start / End Page: 4828 - 4840 Identifier: ISSN: 1552-5279
CoNE: https://pure.mpg.de/cone/journals/resource/2352-8729