English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Foxd3 controls heterochromatin-mediated repression of repeat elements and 2-cell state transcription

Puri, D., Koschorz, B., Engist, B., Onishi-Seebacher, M., Ryan, D., Soujanya, M., et al. (2021). Foxd3 controls heterochromatin-mediated repression of repeat elements and 2-cell state transcription. EMBO Reports, 22: e53180. doi:10.15252/embr.202153180.

Item is

 

show all

Basic

hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000D-17D9-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-17DA-4
Genre: Journal Article

Files

hide Files
:
10.15252_embr.202153180.pdf (Publisher version), 3MB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-000D-17DB-3
Name:
10.15252_embr.202153180.pdf
Description:
-
OA-Status:
Not specified
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
2021
Copyright Info:
The Authors. Published under the terms of the CC BY 4.0 license
License:
http://creativecommons.org/licenses/by/4.0/

Locators

hide
Locator:
https://www.embopress.org/doi/full/10.15252/embr.202153180 (Publisher version)
Description:
-
OA-Status:
Not specified

Creators

hide
 Creators:
Puri, Deepika1, Author
Koschorz, Birgit1, Author
Engist, Bettina1, Author
Onishi-Seebacher, Megumi1, Author
Ryan, Devon1, Author
Soujanya, Mamilla2, Author
Montavon, Thomas1, Author
Affiliations:
1Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              
2External Organizations, ou_persistent22              

Content

hide
Free keywords: 2-cell-like cells; Foxd3; MERVL; heterochromatin; transcription factor
 Abstract: Repeat element transcription plays a vital role in early embryonic development. The expression of repeats such as MERVL characterises mouse embryos at the 2-cell stage and defines a 2-cell-like cell (2CLC) population in a mouse embryonic stem cell culture. Repeat element sequences contain binding sites for numerous transcription factors. We identify the forkhead domain transcription factor FOXD3 as a regulator of major satellite repeats and MERVL transcription in mouse embryonic stem cells. FOXD3 binds to and recruits the histone methyltransferase SUV39H1 to MERVL and major satellite repeats, consequentially repressing the transcription of these repeats by the establishment of the H3K9me3 heterochromatin modification. Notably, depletion of FOXD3 leads to the de-repression of MERVL and major satellite repeats as well as a subset of genes expressed in the 2-cell state, shifting the balance between the stem cell and 2-cell-like population in culture. Thus, FOXD3 acts as a negative regulator of repeat transcription, ascribing a novel function to this transcription factor.

Details

hide
Language(s): eng - English
 Dates: 2021-10-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.15252/embr.202153180
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

hide
Title: EMBO Reports
  Other : EMBO Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford, UK : Published for EMBO by Oxford University Press
Pages: - Volume / Issue: 22 Sequence Number: e53180 Start / End Page: - Identifier: ISSN: 1469-221X
CoNE: https://pure.mpg.de/cone/journals/resource/110978984569661