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キーワード:
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要旨:
Intracellular protein levels are controlled by protein synthesis and degradation. A major proteolytic pathway of eukaryotes is ATP–dependent and requires the covalent attachment of ubiquitin, a small and highly conserved protein, to proteolytic substrates prior to degradation (for reviews see Finley & Chau 1991, Hershko & Ciechanover 1992, and Jentsch 1992a and b). This pathway is highly selective and mediates the elimination of abnormal proteins and controls the half–lives of some regulatory proteins. Known targets include transcriptional regulators (Hochstrasser et al. 1991), p53 (Scheffner et al. 1990), the Mos kinase (Nishizawa et al. 1992) and cyclins (Glotzer et al. 1991).
