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  High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex

Haenelt, D., Trampel, R., Nasr, S., Polimeni, J. R., Tootell, R. B. H., Sereno, M. I., et al. (2023). High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex. eLife, 12: e78756. doi:10.7554/eLife.78756.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-1E70-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-1E71-3
Genre: Journal Article

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Haenelt_2023_High-resolutionQuantitative.pdf
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2023
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Copyright © 2023 Haenelt et al.
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https://elifesciences.org/articles/78756 (Publisher version)
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 Creators:
Haenelt, Daniel, Author
Trampel, Robert, Author
Nasr, Shahin, Author
Polimeni, Jonathan R., Author
Tootell, Roger B. H., Author
Sereno, Martin I., Author
Pine, Kerrin J., Author
Edwards, Luke J., Author
Helbling, Saskia1, 2, Author
Weiskopf, Nikolaus, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Poeppel Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381225              

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Free keywords: Animals Humans *Electron Transport Complex IV/metabolism Brain Mapping *Visual Cortex/physiology Vision Disparity Magnetic Resonance Imaging 7 T MRI columnar fMRI human myelin neuroscience quantitative MRI secondary visual cortex Planck Institute for Human Cognitive and Brain Sciences has an institutional research agreement with Siemens Healthcare. Nikolaus Weiskopf holds a patent on MRI data acquisition during spoiler gradients (United States Patent 10,401,453). Nikolaus Weiskopf was a speaker at an event organized by Siemens Healthcare and was reimbursed for the travel expenses
 Abstract: The characterization of cortical myelination is essential for the study of structure-function relationships in the human brain. However, knowledge about cortical myelination is largely based on post-mortem histology, which generally renders direct comparison to function impossible. The repeating pattern of pale-thin-pale-thick stripes of cytochrome oxidase (CO) activity in the primate secondary visual cortex (V2) is a prominent columnar system, in which histology also indicates different myelination of thin/thick versus pale stripes. We used quantitative magnetic resonance imaging (qMRI) in conjunction with functional magnetic resonance imaging (fMRI) at ultra-high field strength (7 T) to localize and study myelination of stripes in four human participants at sub-millimeter resolution in vivo. Thin and thick stripes were functionally localized by exploiting their sensitivity to color and binocular disparity, respectively. Resulting functional activation maps showed robust stripe patterns in V2 which enabled further comparison of quantitative relaxation parameters between stripe types. Thereby, we found lower longitudinal relaxation rates (R1) of thin and thick stripes compared to surrounding gray matter in the order of 1–2%, indicating higher myelination of pale stripes. No consistent differences were found for effective transverse relaxation rates (R2*). The study demonstrates the feasibility to investigate structure-function relationships in living humans within one cortical area at the level of columnar systems using qMRI.

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 Dates: 2023-03-08
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.7554/eLife.78756
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Title: eLife
Source Genre: Journal
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Pages: - Volume / Issue: 12 Sequence Number: e78756 Start / End Page: - Identifier: ISSN: 2050-084X