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  A neuron model with unbalanced synaptic weights explains the asymmetric effects of anaesthesia on the auditory cortex

López-Jury, L., García-Rosales, F., González-Palomares, E., Wetekam, J., Pasek, M., & Hechavarria, J. C. (2023). A neuron model with unbalanced synaptic weights explains the asymmetric effects of anaesthesia on the auditory cortex. PLOS Biology, 21(2): e3002013. doi:10.1371/journal.pbio.3002013.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000D-1E8A-7 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-1E8B-6
Genre: Zeitschriftenartikel

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Lopez-Jury_2023_ANeuronModel.pdf (Verlagsversion), 6MB
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https://hdl.handle.net/21.11116/0000-000D-1E8C-5
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Lopez-Jury_2023_ANeuronModel.pdf
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Gold
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Copyright Datum:
2023
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Copyright © 2023 López-Jury et al.
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https://creativecommons.org/licenses/by/4.0/

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externe Referenz:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002013 (Verlagsversion)
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OA-Status:
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 Urheber:
López-Jury, Luciana, Autor
García-Rosales, Francisco1, 2, Autor
González-Palomares, Eugenia, Autor
Wetekam, Johannes, Autor
Pasek, Michael, Autor
Hechavarria, Julio C., Autor
Malmierca, Manuel S., Herausgeber
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Poeppel Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381225              

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Schlagwörter: Animals *Auditory Cortex/physiology Acoustic Stimulation *Ketamine/pharmacology *Chiroptera/physiology *Anesthesia Neurons/physiology Auditory Perception/physiology
 Zusammenfassung: Substantial progress in the field of neuroscience has been made from anaesthetized preparations. Ketamine is one of the most used drugs in electrophysiology studies, but how ketamine affects neuronal responses is poorly understood. Here, we used in vivo electrophysiology and computational modelling to study how the auditory cortex of bats responds to vocalisations under anaesthesia and in wakefulness. In wakefulness, acoustic context increases neuronal discrimination of natural sounds. Neuron models predicted that ketamine affects the contextual discrimination of sounds regardless of the type of context heard by the animals (echolocation or communication sounds). However, empirical evidence showed that the predicted effect of ketamine occurs only if the acoustic context consists of low-pitched sounds (e.g., communication calls in bats). Using the empirical data, we updated the naïve models to show that differential effects of ketamine on cortical responses can be mediated by unbalanced changes in the firing rate of feedforward inputs to cortex, and changes in the depression of thalamo-cortical synaptic receptors. Combined, our findings obtained in vivo and in silico reveal the effects and mechanisms by which ketamine affects cortical responses to vocalisations.

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 Datum: 2023-02-21
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1371/journal.pbio.3002013
 Art des Abschluß: -

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Titel: PLOS Biology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 21 (2) Artikelnummer: e3002013 Start- / Endseite: - Identifikator: ISSN: 1545-7885