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  Sensory gating functions of the auditory thalamus: Adaptation and modulations through noise-exposure and high-frequency stimulation in rats

Zare, A., van Zwieten, G., Kotz, S. A., Temel, Y., Almasabi, F., Schultz, B. G., et al. (2023). Sensory gating functions of the auditory thalamus: Adaptation and modulations through noise-exposure and high-frequency stimulation in rats. Behavioural Brain Research, 450: 114498. doi:10.1016/j.bbr.2023.114498.

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 Creators:
Zare, Aryo1, 2, Author
van Zwieten, Gusta1, 3, Author
Kotz, Sonja A.4, 5, Author                 
Temel, Yasin1, 2, Author
Almasabi, Faris1, 6, Author
Schultz, Benjamin G.4, Author
Schwartze, Michael4, Author           
Janssen, Marcus L.F.1, 7, Author
Affiliations:
1School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands, ou_persistent22              
2Department of Neurosurgery, Maastricht University, the Netherlands, ou_persistent22              
3Department of Ear, Nose and Throat/Head and Neck Surgery, Maastricht University, the Netherlands, ou_persistent22              
4Department of Neuropsychology and Psychopharmacology, Maastricht University, the Netherlands, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
6Department of Physiology, Faculty of Medicine, King Khalid University, Abha, Saudi Arabia, ou_persistent22              
7Department of Clinical Neurophysiology, Maastricht University, the Netherlands, ou_persistent22              

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Free keywords: Sensory gating (SG); Evoked potentials (EP); Deviance processing; Medial geniculate body (MGB); High-frequency stimulation (HFS)
 Abstract: The medial geniculate body (MGB) of the thalamus is an obligatory relay for auditory processing. A breakdown of adaptive filtering and sensory gating at this level may lead to multiple auditory dysfunctions, while high-frequency stimulation (HFS) of the MGB might mitigate aberrant sensory gating. To further investigate the sensory gating functions of the MGB, this study (i) recorded electrophysiological evoked potentials in response to continuous auditory stimulation, and (ii) assessed the effect of MGB HFS on these responses in noise-exposed and control animals. Pure-tone sequences were presented to assess differential sensory gating functions associated with stimulus pitch, grouping (pairing), and temporal regularity. Evoked potentials were recorded from the MGB and acquired before and after HFS (100 Hz). All animals (unexposed and noise-exposed, pre- and post-HFS) showed gating for pitch and grouping. Unexposed animals also showed gating for temporal regularity not found in noise-exposed animals. Moreover, only noise-exposed animals showed restoration comparable to the typical EP amplitude suppression pattern following MGB HFS. The current findings confirm adaptive thalamic sensory gating based on different sound characteristics and provide evidence that temporal regularity affects MGB auditory signaling.

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Language(s): eng - English
 Dates: 2023-05-122023-02-282023-05-142023-05-162023-07-26
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.bbr.2023.114498
Other: epub 2023
PMID: 37201892
 Degree: -

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Title: Behavioural Brain Research
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 450 Sequence Number: 114498 Start / End Page: - Identifier: ISSN: 0166-4328
CoNE: https://pure.mpg.de/cone/journals/resource/954925482632