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  Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness

Luppi, A. I., Cabral, J., Cofre, R., Mediano, P. A., Rosas, F. E., Qureshi, A. Y., Kuceyeski, A., Tagliazucchi, E., Raimondo, F., Deco, G., Shine, J. M., Kringelbach, M. L., Orio, P., Ching, S., Sanz-Perl, Y., Diringer, M. N., Stevens, R. D., & Sitt, J. D. (2023). Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness. NeuroImage, 275:. doi:10.1016/j.neuroimage.2023.120162.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000D-2CCB-E 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-436F-C
資料種別: 学術論文

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Luppi_2023.pdf (出版社版), 2MB
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ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-000D-4370-9
ファイル名:
Luppi_2023.pdf
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Gold
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公開
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application/pdf / [MD5]
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CCライセンス:
https://creativecommons.org/licenses/by/4.0/

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作成者

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 作成者:
Luppi, Andrea I.1, 著者
Cabral, Joana1, 著者
Cofre, Rodrigo1, 著者
Mediano, Pedro A.M.1, 著者
Rosas, Fernando E.1, 著者
Qureshi, Abid Y.1, 著者
Kuceyeski, Amy1, 著者
Tagliazucchi, Enzo1, 著者
Raimondo, Federico1, 著者
Deco, Gustavo2, 著者           
Shine, James M.1, 著者
Kringelbach, Morten L.1, 著者
Orio, Patricio1, 著者
Ching, ShiNung1, 著者
Sanz-Perl, Yonatan1, 著者
Diringer, Michael N.1, 著者
Stevens, Robert D.1, 著者
Sitt, Jacobo Diego1, 著者
所属:
1External Organizations, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

内容説明

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キーワード: Disorders of consciousness; Computational models; Generative models; Statistical models; Biophysical models; Machine learning
 要旨: Disorders of consciousness are complex conditions characterised by persistent loss of responsiveness due to brain injury. They present diagnostic challenges and limited options for treatment, and highlight the urgent need for a more thorough understanding of how human consciousness arises from coordinated neural activity. The increasing availability of multimodal neuroimaging data has given rise to a wide range of clinically- and scientifically-motivated modelling efforts, seeking to improve data-driven stratification of patients, to identify causal mechanisms for patient pathophysiology and loss of consciousness more broadly, and to develop simulations as a means of testing in silico potential treatment avenues to restore consciousness. As a dedicated Working Group of clinicians and neuroscientists of the international Curing Coma Campaign, here we provide our framework and vision to understand the diverse statistical and generative computational modelling approaches that are being employed in this fast-growing field. We identify the gaps that exist between the current state-of-the-art in statistical and biophysical computational modelling in human neuroscience, and the aspirational goal of a mature field of modelling disorders of consciousness; which might drive improved treatments and outcomes in the clinic. Finally, we make several recommendations for how the field as a whole can work together to address these challenges.

資料詳細

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言語: eng - English
 日付: 2023-04-162023-01-152023-05-092023-05-15
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1016/j.neuroimage.2023.120162
その他: epub 2023
PMID: 37196986
 学位: -

関連イベント

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訴訟

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Project information

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Project name : -
Grant ID : OPP 1144
Funding program : -
Funding organization : Gates Cambridge Trust
Project name : -
Grant ID : 945539
Funding program : Horizon 2020
Funding organization : Human Brain Project (HBP)
Project name : -
Grant ID : R01NS102646; RF1MH123232; R01NS130693
Funding program : -
Funding organization : US National Institutes of Health (NIH)
Project name : -
Grant ID : LCF/BQ/PR22/11920014
Funding program : -
Funding organization : La Caixa Foundation
Project name : -
Grant ID : 1193857
Funding program : -
Funding organization : Australian National Health and Medical Research Council (NHMRC)
Project name : -
Grant ID : 1211750; 1220995
Funding program : -
Funding organization : National Fund for Scientific and Technological Development (FONDECYT)
Project name : -
Grant ID : AC3E FB0008
Funding program : -
Funding organization : Centro Basal
Project name : Marie Sklodowska-Curie grant
Grant ID : 896354
Funding program : Horizon 2020
Funding organization : European Union
Project name : Centre for Eudaimonia and Human Flourishing
Grant ID : -
Funding program : -
Funding organization : Pettit and Carlsberg Foundations
Project name : Center for Music in the Brain
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation (DNRF)
Project name : ModelDXConsciousness
Grant ID : -
Funding program : -
Funding organization : FLAG-ERA

出版物 1

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出版物名: NeuroImage
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Orlando, FL : Academic Press
ページ: - 巻号: 275 通巻号: 120162 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166