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  Measuring pico-Newton forces with lipid anchors as force sensors in molecular dynamics simulations

Kav, B., Weikl, T. R., & Schneck, E. (2023). Measuring pico-Newton forces with lipid anchors as force sensors in molecular dynamics simulations. The Journal of Physical Chemistry B, 127(18), 4081-4089. doi:10.1021/acs.jpcb.3c00063.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-31C0-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0010-47C8-D
Genre: Journal Article

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 Creators:
Kav, Batuhan1, Author                 
Weikl, Thomas R.2, Author                 
Schneck, Emanuel3, Author                 
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1Thomas Weikl, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863330              
2Thomas Weikl, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_3360039              
3Emanuel Schneck, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2074300              

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 Abstract: Binding forces between biomolecules are ubiquitous in nature but sometimes as weak as a few pico-Newtons (pN). In many cases, the binding partners are attached to biomembranes with the help of a lipid anchor. One important example are glycolipids that promote membrane adhesion through weak carbohydrate–carbohydrate binding between adjacent membranes. Here, we use molecular dynamics (MD) simulations to quantify the forces generated by bonds involving membrane-anchored molecules. We introduce a method in which the protrusion of the lipid anchors from the membrane acts as the force sensor. Our results with two different glycolipids reveal binding forces of up to 20 pN and corroborate the recent notion that carbohydrate–carbohydrate interactions are generic rather than specific.

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Language(s): eng - English
 Dates: 2023-04-262023
 Publication Status: Issued
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 Identifiers: DOI: 10.1021/acs.jpcb.3c00063
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Title: The Journal of Physical Chemistry B
  Abbreviation : J. Phys. Chem. B
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Chemical Society
Pages: - Volume / Issue: 127 (18) Sequence Number: - Start / End Page: 4081 - 4089 Identifier: ISSN: 1520-6106