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  In silico optimization of iopamidol CEST MRI for renal pH mapping at 3 Tesla

Stabinska, J., Zaiss, M., Bibic, A., Sedaghat, F., Sadowsky, C., van Zijl, P., et al. (2023). In silico optimization of iopamidol CEST MRI for renal pH mapping at 3 Tesla. Poster presented at 2023 ISMRM & ISMRT Annual Meeting & Exhibition (ISMRM 2023), Toronto, Canada.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-35AE-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-35AF-3
Genre: Poster

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https://submissions.mirasmart.com/ISMRM2023/Itinerary/ConferenceMatrixEventDetail.aspx?ses=D-83 (Abstract)
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 Creators:
Stabinska, J, Author
Zaiss, M1, Author                 
Bibic, A, Author
Sedaghat, F, Author
Sadowsky, C, Author
van Zijl, PCM, Author
McMahon, MT, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: In vivo optimization of CEST iopamidol contrast in human subjects is complicated and requires multiple examinations and injections of the agent. To address this challenge, we propose application of a numerical approach that utilizes exchange rates determined under physiological conditions at 17.6T to perform kidney-like multi-pool Bloch-McConnell simulations for in silico optimization of saturation parameters for 3T applications. Our results suggest that the iopamidol-based CEST MRI is sensitive to pH in the range between 6 and 7.2 with the optimal results when short CEST saturation pulses (3x100 ms), low B1 strength (B1~0.8 µT) and short recovery time (Trec~T1w) are applied.

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 Dates: 2023-05
 Publication Status: Published online
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Title: 2023 ISMRM & ISMRT Annual Meeting & Exhibition (ISMRM 2023)
Place of Event: Toronto, Canada
Start-/End Date: 2023-06-03 - 2023-06-08

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Title: 2023 ISMRM & ISMRT Annual Meeting & Exhibition (ISMRM 2023)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2991 Start / End Page: - Identifier: -