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  The development of oscillatory and aperiodic resting state activity is linked to a sensitive period in humans

Ossandón, J. P., Stange, L., Gudi-Mindermann, H., Rimmele, J. M., Sourav, S., Bottari, D., Kekunnaya, R., & Röder, B. (2023). The development of oscillatory and aperiodic resting state activity is linked to a sensitive period in humans. NeuroImage, 275:. doi:10.1016/j.neuroimage.2023.120171.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000D-47AF-F 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-47B2-A
資料種別: 学術論文

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neu-23-rim-01-development.pdf (出版社版), 3MB
ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-000D-47B1-B
ファイル名:
neu-23-rim-01-development.pdf
説明:
OA
OA-Status:
Gold
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公開
MIMEタイプ / チェックサム:
application/pdf / [MD5]
技術的なメタデータ:
著作権日付:
2023
著作権情報:
© 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license

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 作成者:
Ossandón, José P.1, 著者
Stange, Liesa1, 著者
Gudi-Mindermann, Helene1, 2, 著者
Rimmele, Johanna Maria3, 4, 5, 著者                 
Sourav, Suddha1, 著者
Bottari, Davide1, 著者
Kekunnaya, Ramesh6, 著者
Röder, Brigitte1, 6, 著者
所属:
1Biological Psychology and Neuropsychology, University of Hamburg, Hamburg, Germany, ou_persistent22              
2Institute of Public Health and Nursing Research, University of Bremen, Bremen, Germany, ou_persistent22              
3Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421697              
4Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany , ou_persistent22              
5Max Planck NYU Center for Language, Music, and Emotion , Frankfurt am Main Germany, New York, NY, USA, ou_persistent22              
6Child Sight Institute, Jasti V Ramanamma Children's Eye Care Center, LV Prasad Eye Institute, Hyderabad, India, ou_persistent22              

内容説明

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キーワード: Congenital blindnessSight-recoveryAlphaAperiodic activityEEG resting state
 要旨: Congenital blindness leads to profound changes in electroencephalographic (EEG) resting state activity. A well-known consequence of congenital blindness in humans is the reduction of alpha activity which seems to go together with increased gamma activity during rest. These results have been interpreted as indicating a higher excitatory/inhibitory (E/I) ratio in visual cortex compared to normally sighted controls. Yet it is unknown whether the spectral profile of EEG during rest would recover if sight were restored. To test this question, the present study evaluated periodic and aperiodic components of the EEG resting state power spectrum. Previous research has linked the aperiodic components, which exhibit a power-law distribution and are operationalized as a linear fit of the spectrum in log-log space, to cortical E/I ratio. Moreover, by correcting for the aperiodic components from the power spectrum, a more valid estimate of the periodic activity is possible. Here we analyzed resting state EEG activity from two studies involving (1) 27 permanently congenitally blind adults (CB) and 27 age-matched normally sighted controls (MCB); (2) 38 individuals with reversed blindness due to bilateral, dense, congenital cataracts (CC) and 77 age-matched sighted controls (MCC). Based on a data driven approach, aperiodic components of the spectra were extracted for the low frequency (Lf-Slope 1.5 to 19.5 Hz) and high frequency (Hf-Slope 20 to 45 Hz) range. The Lf-Slope of the aperiodic component was significantly steeper (more negative slope), and the Hf-Slope of the aperiodic component was significantly flatter (less negative slope) in CB and CC participants compared to the typically sighted controls. Alpha power was significantly reduced, and gamma power was higher in the CB and the CC groups. These results suggest a sensitive period for the typical development of the spectral profile during rest and thus likely an irreversible change in the E/I ratio in visual cortex due to congenital blindness. We speculate that these changes are a consequence of impaired inhibitory circuits and imbalanced feedforward and feedback processing in early visual areas of individuals with a history of congenital blindness.

資料詳細

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言語: eng - English
 日付: 2023-04-272023-01-312023-05-152023-05-152023-07-15
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1016/j.neuroimage.2023.120171
 学位: -

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出版物 1

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出版物名: NeuroImage
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Orlando, FL : Academic Press
ページ: - 巻号: 275 通巻号: 120171 開始・終了ページ: - 識別子(ISBN, ISSN, DOIなど): ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166