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  Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1

Dennerlein, S., Rehling, P., & Richter-Dennerlein, R. (2023). Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1. FEBS Letters, 597(12), 1569-1578. doi:10.1002/1873-3468.14671.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-4991-D Version Permalink: https://hdl.handle.net/21.11116/0000-000D-709E-3
Genre: Journal Article

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FEBS Letters - 2023 - Dennerlein.pdf (Publisher version), 336KB
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Dennerlein, Sven, Author
Rehling, Peter1, Author           
Richter-Dennerlein, Ricarda, Author
Affiliations:
1MPI-NAT Fellow Mitochondrial Biogenesis and Assembly of membrane Protein Complexes, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3505610              

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 Abstract: Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F1Fo ATP synthase and four mitochondrial respiratory chain complexes, the terminal enzyme of which is the cytochrome c oxidase (complex IV) that transfers electrons to oxygen, generating water. Complex IV comprises of 14 structural subunits of dual genetic origin: while the three core subunits are mitochondrial encoded, the remaining constituents are encoded by the nuclear genome. Hence, the assembly of complex IV requires the coordination of two spatially separated gene expression machinery. Recent efforts elucidated an increasing number of proteins involved in mitochondrial gene expression, which are linked to complex IV assembly. Additionally, several COX1 biogenesis factors have been intensively biochemically investigated and an increasing number of structural snapshots shed light on the organization of macromolecular complexes such as the mitoribosome or the cytochrome c oxidase. Here, we focus on COX1 translation regulation and highlight the advanced understanding of early steps during COX1 assembly and its link to mitochondrial translation regulation.

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Language(s): eng - English
 Dates: 2023-05-292023-06
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/1873-3468.14671
 Degree: -

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Project name : -
Grant ID : 390729940
Funding program : Multiscale Bioimaging: Von molekularen Maschinen zu Netzwerken erregbarer Zellen (EXC 2067)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 264061860
Funding program : Transportmaschinerien und Kontaktstellen zellulärer Kompartimente (SFB 1190)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 401510699
Funding program : Architektur und Heterogenität der inneren mitochondrialen Membran auf der Nanoskala (FOR 2848)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 377782854
Funding program : Epileptogenese von genetischen Epilepsien (FOR 2715)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 597 (12) Sequence Number: - Start / End Page: 1569 - 1578 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501