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  Maturation of amyloid β fibrils alters their molecular stability

Becker, S., Giller, K., Sieme, D., & Rezaei-Ghaleh, N. (2023). Maturation of amyloid β fibrils alters their molecular stability. Physical Chemistry Chemical Physics, 25, 15099-15103. doi:10.1039/d3cp01276j.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-5472-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-5473-3
Genre: Journal Article
Other : Maturation of amyloid beta fibrils alters their molecular stability

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 Creators:
Becker, Stefan1, Author           
Giller, Karin1, Author           
Sieme, Daniel1, Author           
Rezaei-Ghaleh, Nasrollah, Author
Affiliations:
1Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350124              

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 Abstract: Little is known about how maturation of Alzheimer's disease-related amyloid β (Aβ) fibrils alters their stability and potentially influences their spreading in the brain. Using high-pressure NMR, we show that progression from early to late Aβ40 aggregates enhances the kinetic stability, while ageing during weeks to months enhances their thermodynamic stability.

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Language(s): eng - English
 Dates: 2023-05-232023
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/d3cp01276j
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Project name : N. R.-G. acknowledges the Deutsche Forschungsgemeinschaft (German Research Foundation, DFG) for research grants RE 3655/2-1 and 3655/2-3.
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Title: Physical Chemistry Chemical Physics
  Abbreviation : Phys. Chem. Chem. Phys.
Source Genre: Journal
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Publ. Info: Cambridge, England : Royal Society of Chemistry
Pages: - Volume / Issue: 25 Sequence Number: - Start / End Page: 15099 - 15103 Identifier: ISSN: 1463-9076
CoNE: https://pure.mpg.de/cone/journals/resource/954925272413_1