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  Closely related Bacteroides of the murine intestinal microbiota affect each other’s growth positively or negatively

Fokt, H., Sakalyte, G., Unni, R. G., Abukhalaf, M., Cassidy, L., Marinos, G., et al. (in preparation). Closely related Bacteroides of the murine intestinal microbiota affect each other’s growth positively or negatively.

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 Urheber:
Fokt, Hanna1, Autor                 
Sakalyte, Gabija, Autor
Unni, Rahul Govindan1, 2, Autor                 
Abukhalaf, Mohammad, Autor
Cassidy, Liam, Autor
Marinos, Georgios, Autor
Godfroid, Maxime, Autor
Kinfu, Birhanu M., Autor
Schmitz, Ruth A., Autor
Kaleta, Christoph, Autor
Tholey, Andreas, Autor
Baines, John F.1, Autor                 
Dagan, Tal, Autor
Unterweger, Daniel3, Autor                 
Affiliations:
1Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_3371474              
2IMPRS for Evolutionary Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445639              
3Guest Group Infection Biology (Unterweger), Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_3552274              

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 Zusammenfassung: The mammalian intestine is a unique ecosystem for thousands of bacterial species and strains. How naturally coexisting bacteria of the microbiota interact with each other is not yet fully understood. Here, we isolated formerly coexisting, closely related strains of the genus Bacteroides from the intestines of healthy, wild-derived mice. The effect of one strain on another strain’s growth was tested in 169 pairs in vitro. We find a vast diversity of growth promoting and growth inhibiting activities. A strong positive effect was observed between two strains with differing metabolisms. Growth inhibition among a subset of strains was associated with the known bacterial toxin bacteroidetocin B. Across all strains, we observed growth promotion more often than growth inhibition. The effects were independent of two strains belonging to the same or different species. In some cases, one species differed in its effect on another according to host origin. These findings on obligate host-associated bacteria demonstrate that closely related and naturally coexisting strains have the potential to affect each other’s growth positively or negatively. These results have implications for our basic understanding of host-associated microbes and the design of synthetic microbial communities.

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Sprache(n): eng - English
 Datum: 2023-03-05
 Publikationsstatus: Keine Angabe
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 Art der Begutachtung: Keine Begutachtung
 Identifikatoren: DOI: 10.1101/2023.03.05.530569
 Art des Abschluß: -

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