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  Functional genomics of marine and freshwater sticklebacks

Jones, F. (2015). Functional genomics of marine and freshwater sticklebacks. In 15th Congress of the European Society for Evolutionary Biology (ESEB 2015) (pp. 85-86).

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-57E1-3 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-57E4-0
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https://eseb.org/wp-content/uploads/2018/08/2015_Abstracts.pdf (Abstract)
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Jones, F1, Author                 
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1Jones Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3008689              

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 Abstract: Colonisation of new freshwater habitats has resulted in the repeated adaptive divergence of freshwater sticklebacks from their ancestral marine ecotype. We use these powerful biological replicates of the evolutionary process to identify and functionally dissect the molecular mechanisms underlying adaptive divergence and reproductive isolation. I'll describe how we are using whole genome sequencing and population genomics of stickleback species pairs to identify high-resolution sets of loci underlying parallel adaptive divergence. Many loci fall in non-coding parts of the genome, suggesting non-coding regulatory elements may be particularly important in adaptation. We use a range of methods to functionally dissect the phenotypic effect of these loci. These include transgenic methods to test for divergence in the regulatory potential of marine and freshwater adaptive haplotypes, and powerful new genome editing techniques to knock-out and knock-in adaptive loci. Our ultimate aim is to understand the fitness effects of these loci in natural populations. To do this we study the fitness and survival of naturally occuring recombinant individuals in contact zones between marine and freshwater forms. The ability to identify and functionally dissect adaptive loci in sticklebacks provides powerful insights into the molecular mechanisms underlying adaptation in natural populations.

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 Dates: 2015-08
 Publication Status: Published online
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Title: 15th Congress of the European Society for Evolutionary Biology (ESEB 2015)
Place of Event: Lausanne, Switzerland
Start-/End Date: 2015-08-10 - 2015-08-14

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Title: 15th Congress of the European Society for Evolutionary Biology (ESEB 2015)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 52566 Start / End Page: 85 - 86 Identifier: -