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  Noise and Air Pollution as Risk Factors for Hypertension: Part II—Pathophysiologic Insight

Hahad, O., Rajagopalan, S., Lelieveld, J., Sørensen, M., Kuntic, M., Daiber, A., et al. (2023). Noise and Air Pollution as Risk Factors for Hypertension: Part II—Pathophysiologic Insight. Hypertension, 80, 1384-1392. doi:10.1161/HYPERTENSIONAHA.123.20617.

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 Creators:
Hahad, Omar, Author
Rajagopalan, Sanjay, Author
Lelieveld, Jos1, Author           
Sørensen, Mette, Author
Kuntic, Marin, Author
Daiber, Andreas, Author
Basner, Mathias, Author
Nieuwenhuijsen, Mark, Author
Brook, Robert D., Author
Münzel, Thomas, Author
Affiliations:
1Atmospheric Chemistry, Max Planck Institute for Chemistry, Max Planck Society, ou_1826285              

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 Abstract: Traffic noise and air pollution are environmental stressors found to increase risk for cardiovascular events. The burden of disease attributable to environmental stressors and cardiovascular disease globally is substantial, with a need to better understand the contribution of specific risk factors that may underlie these effects. Epidemiological observations and experimental evidence from animal models and human controlled exposure studies suggest an essential role for common mediating pathways. These include sympathovagal imbalance, endothelial dysfunction, vascular inflammation, increased circulating cytokines, activation of central stress responses, including hypothalamic and limbic pathways, and circadian disruption. Evidence also suggests that cessation of air pollution or noise through directed interventions alleviates increases in blood pressure and intermediate surrogate pathways, supporting a causal link. In the second part of this review, we discuss the current understanding of mechanisms underlying and current gaps in knowledge and opportunities for new research.

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Language(s): eng - English
 Dates: 2023-04-19
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1161/HYPERTENSIONAHA.123.20617
 Degree: -

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Title: Hypertension
Source Genre: Journal
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Publ. Info: Philadelphia, PA : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 80 Sequence Number: - Start / End Page: 1384 - 1392 Identifier: ISSN: 0194-911X
CoNE: https://pure.mpg.de/cone/journals/resource/954925490865