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  Modulation of limbic resting-state networks by subthalamic nucleus deep brain stimulation

Eraifej, J., Cabral, J., Fernandes, H. M., Kahan, J., He, S., Mancini, L., et al. (2023). Modulation of limbic resting-state networks by subthalamic nucleus deep brain stimulation. Network Neuroscience, 7(2), 478-495. doi:10.1162/netn_a_00297.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-67F3-D Version Permalink: https://hdl.handle.net/21.11116/0000-000D-67F4-C
Genre: Journal Article

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 Creators:
Eraifej, John1, Author
Cabral, Joana2, 3, 4, Author
Fernandes, Henrique M.4, Author
Kahan, Joshua5, Author
He, Shenghong6, Author
Mancini, Laura7, 8, Author
Thornton, John7, 8, Author
White, Mark7, 8, Author
Yousry, Tarek7, 8, Author
Zrinzo, Ludvic5, Author
Akram, Harith5, Author
Limousin, Patricia5, Author
Foltynie, Tom5, Author
Aziz, Tipu Z.1, Author
Deco, Gustavo9, 10, 11, Author           
Kringelbach, Morten3, 4, 12, Author
Green, Alexander L.1, Author
Affiliations:
1Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom, ou_persistent22              
2ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
3Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
4Department of Clinical Medicine, Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
5Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Germany, ou_persistent22              
6Nuffield Department Clinical Neurosciences, University of Oxford, United Kingdom, ou_persistent22              
7Neuroradiological Academic Unit, Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
8Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ou_persistent22              
9Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
10Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, ou_persistent22              
11Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
12Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              

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Free keywords: Deep brain stimulation; Functional MRI; Leading Eigenvector Dynamics Analysis; Limbic network; Parkinson’s disease; Subthalamic nucleus
 Abstract: Beyond the established effects of subthalamic nucleus deep brain stimulation (STN-DBS) in reducing motor symptoms in Parkinson's disease, recent evidence has highlighted the effect on non-motor symptoms. However, the impact of STN-DBS on disseminated networks remains unclear. This study aimed to perform a quantitative evaluation of network-specific modulation induced by STN-DBS using Leading Eigenvector Dynamics Analysis (LEiDA). We calculated the occupancy of resting-state networks (RSNs) in functional MRI data from 10 patients with Parkinson's disease implanted with STN-DBS and statistically compared between ON and OFF conditions. STN-DBS was found to specifically modulate the occupancy of networks overlapping with limbic RSNs. STN-DBS significantly increased the occupancy of an orbitofrontal limbic subsystem with respect to both DBS OFF (p = 0.0057) and 49 age-matched healthy controls (p = 0.0033). Occupancy of a diffuse limbic RSN was increased with STN-DBS OFF when compared with healthy controls (p = 0.021), but not when STN-DBS was ON, which indicates rebalancing of this network. These results highlight the modulatory effect of STN-DBS on components of the limbic system, particularly within the orbitofrontal cortex, a structure associated with reward processing. These results reinforce the value of quantitative biomarkers of RSN activity in evaluating the disseminated impact of brain stimulation techniques and the personalization of therapeutic strategies.

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Language(s): eng - English
 Dates: 2021-11-082022-11-292023-06-30
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1162/netn_a_00297
Other: eCollection 2023
PMID: 37397890
PMC: PMC10312264
 Degree: -

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Project name : -
Grant ID : UIDB/50026/2020; UIDP/50026/2020; CEECIND/03325/2017
Funding program : -
Funding organization : National Institute of Health Research (NIHR)
Project name : BRAINSTIM
Grant ID : LCF/BQ/PR22/11920014
Funding program : -
Funding organization : La Caixa
Project name : -
Grant ID : -
Funding program : -
Funding organization : Astor Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Rosetrees Trust
Project name : -
Grant ID : -
Funding program : -
Funding organization : MHMS General Charitable Trust
Project name : -
Grant ID : -
Funding program : -
Funding organization : UK Department of Health’s NIHR Biomedical Research Centres

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Title: Network Neuroscience
Source Genre: Journal
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Publ. Info: Cambridge, MA : MIT Press
Pages: - Volume / Issue: 7 (2) Sequence Number: - Start / End Page: 478 - 495 Identifier: ISSN: 2472-1751
CoNE: https://pure.mpg.de/cone/journals/resource/2472-1751