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  Mutations affecting pigmentation and shape of the adult zebrafish

Haffter, P., Odenthal, J., Mullins, M., Lin, S., Farrell, M., Vogelsang, E., et al. (1996). Mutations affecting pigmentation and shape of the adult zebrafish. Development Genes and Evolution, 206(4), 260-276. doi:10.1007/s004270050051.

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Haffter, P1, Author           
Odenthal, J1, Author           
Mullins, MC1, Author           
Lin, S, Author
Farrell, MJ, Author
Vogelsang, E1, Author                 
Haas, F1, Author           
Brand, M1, Author                 
van Eeden, FJM1, Author           
Furutani-Seiki, M1, Author           
Granato, M1, Author           
Hammerschmidt, M1, Author           
Heisenberg, C-P1, Author           
Jiang, Y-J1, Author           
Kane, DA1, Author           
Kelsh, RN1, Author           
Hopkins, N, Author
Nüsslein-Volhard, C1, Author           
Affiliations:
1Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375716              

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 Abstract: Mutations causing a visible phenotype in the adult serve as valuable visible genetic markers in multicellular genetic model organisms such as Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana. In a large scale screen for mutations affecting early development of the zebrafish, we identified a number of mutations that are homozygous viable or semiviable. Here we describe viable mutations which produce visible phenotypes in the adult fish. These predominantly affect the fins and pigmentation, but also the eyes and body length of the adult. A number of dominant mutations caused visible phenotypes in the adult fish. Mutations in three genes, long fin, another long fin and wanda affected fin formation in the adult. Four mutations were found to cause a dominant reduction of the overall body length in the adult. The adult pigment pattern was found to be changed by dominant mutations in wanda, asterix, obelix, leopard, salz and pfeffer. Among the recessive mutations producing visible phenotypes in the homozygous adult, a group of mutations that failed to produce melanin was assayed for tyrosinase activity. Mutations in sandy produced embryos that failed to express tyrosinase activity. These are potentially useful for using tyrosinase as a marker for the generation of transgenic lines of zebrafish.

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 Dates: 1996-11
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1007/s004270050051
PMID: 24173565
 Degree: -

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Title: Development Genes and Evolution
Source Genre: Journal
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Publ. Info: Berlin : Springer-Verlag
Pages: - Volume / Issue: 206 (4) Sequence Number: - Start / End Page: 260 - 276 Identifier: ISSN: 0949-944X
CoNE: https://pure.mpg.de/cone/journals/resource/954926988121