Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Proteomics separates adult-type diffuse high- grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status

Bader, J. M., Deigendesch, N., Misch, M., Mann, M., Koch, A., & Meissner, F. (2023). Proteomics separates adult-type diffuse high- grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status. Cell Reports Medicine, 4(1): 100877. doi:10.1016/j.xcrm.2022.100877.

Item is

Basisdaten

ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

ausblenden:
 Urheber:
Bader, Jakob Maximilian1, Autor           
Deigendesch, Nikolaus, Autor
Misch, Martin, Autor
Mann, Matthias1, Autor           
Koch, Arend, Autor
Meissner, Felix1, Autor           
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

Inhalt

ausblenden:
Schlagwörter: NF-KAPPA-B; ATPASE INHIBITORY FACTOR-1; ISOCITRATE DEHYDROGENASE 1; CELL-PROLIFERATION; BINDING-PROTEIN; PROMOTER HYPERMETHYLATION; ADJUVANT TEMOZOLOMIDE; TELOMERE MAINTENANCE; PROGNOSTIC BIOMARKER; CONFERS RESISTANCECell Biology; Research & Experimental Medicine;
 Zusammenfassung: High-grade adult-type diffuse gliomas are malignant neuroepithelial tumors with poor survival rates in com-bined chemoradiotherapy. The current WHO classification is based on IDH1/2 mutational and 1p/19q code-letion status. Glioma proteome alterations remain undercharacterized despite their promise for a better mo-lecular patient stratification and therapeutic target identification. Here, we use mass spectrometry to characterize 42 formalin-fixed, paraffin-embedded (FFPE) samples from IDH-wild-type (IDHwt) gliomas, IDH-mutant (IDHmut) gliomas with and without 1p/19q codeletion, and non-neoplastic controls. Based on more than 5,500 quantified proteins and 5,000 phosphosites, gliomas separate by IDH1/2 mutational status but not by 1p/19q status. Instead, IDHmut gliomas split into two proteomic subtypes with widespread per-turbations, including aerobic/anaerobic energy metabolism. Validations with three independent glioma pro-teome datasets confirm these subgroups and link the IDHmut subtypes to the established proneural and classic/mesenchymal subtypes in IDHwt glioma. This demonstrates common phenotypic subtypes across the IDH status with potential therapeutic implications for patients with IDHmut gliomas.

Details

ausblenden:
Sprache(n): eng - English
 Datum: 2023-01-17
 Publikationsstatus: Erschienen
 Seiten: 29
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 001017683900001
DOI: 10.1016/j.xcrm.2022.100877
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

ausblenden:
Titel: Cell Reports Medicine
  Kurztitel : CELL REP MED
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS : Elsevier
Seiten: - Band / Heft: 4 (1) Artikelnummer: 100877 Start- / Endseite: - Identifikator: CoNE: https://pure.mpg.de/cone/journals/resource/2666-3791