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  The genetic architecture of the human cerebral cortex

Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-Conde, L., Bralten, J., Hibar, D. P., et al. (2020). The genetic architecture of the human cerebral cortex. Science, 367(6484): eaay6690. doi:10.1126/science.aay6690.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-7752-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-A49B-B
Genre: Journal Article

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https://research.rug.nl/en/publications/the-genetic-architecture-of-the-human-cerebral-cortex (Any fulltext)
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 Creators:
Grasby, Katrina L.1, Author
Jahanshad, Neda1, Author
Painter, Jodie N.1, Author
Colodro-Conde, Lucía1, Author
Bralten, Janita1, Author
Hibar, Derrek P.1, Author
Lind, Penelope A.1, Author
Pizzagalli, Fabrizio1, Author
Ching, Christopher R. K.1, Author
McMahon, Mary Agnes B.1, Author
Shatokhina, Natalia1, Author
Zsembik, Leo C. P.1, Author
Thomopoulos, Sophia I.1, Author
Zhu, Alyssa H.1, Author
Strike, Lachlan T.1, Author
Agartz, Ingrid1, Author
Alhusaini, Saud1, Author
Almeida, Marcio A. A.1, Author
Alnæs, Dag1, Author
Amlien, Inge K.1, Author
Andersson, Micael1, AuthorArd, Tyler1, AuthorArmstrong, Nicola J.1, AuthorAshley-Koch, Allison1, AuthorAtkins, Joshua R.1, AuthorBernard, Manon1, AuthorBrouwer, Rachel M.1, AuthorBuimer, Elizabeth E. L.1, AuthorBülow, Robin1, AuthorBürger, Christian1, AuthorCannon, Dara M.1, AuthorChakravarty, Mallar1, AuthorChen, Qiang1, AuthorCheung, Joshua W.1, AuthorCouvy-Duchesne, Baptiste1, AuthorDale, Anders M.1, AuthorDalvie, Shareefa1, Authorde Araujo, Tânia K.1, Authorde Zubicaray, Greig I.1, Authorde Zwarte, Sonja M. C.1, Authorden Braber, Anouk1, AuthorDoan, Nhat Trung1, AuthorDohm, Katharina1, AuthorEhrlich, Stefan1, AuthorEngelbrecht, Hannah-Ruth1, AuthorErk, Susanne1, AuthorFan, Chun Chieh1, AuthorFedko, Iryna O.1, AuthorFoley, Sonya F.1, AuthorFord, Judith M.1, AuthorFukunaga, Masaki1, AuthorGarrett, Melanie E.1, AuthorGe, Tian1, AuthorGiddaluru, Sudheer1, AuthorGoldman, Aaron L.1, AuthorGreen, Melissa J.1, AuthorGroenewold, Nynke A.1, AuthorGrotegerd, Dominik1, AuthorGurholt, Tiril P.1, AuthorGutman, Boris A.1, AuthorHansell, Narelle K.1, AuthorHarris, Mathew A.1, AuthorHarrison, Marc B.1, AuthorHaswell, Courtney C.1, AuthorHauser, Michael1, AuthorHerms, Stefan1, AuthorHeslenfeld, Dirk J.1, AuthorHo, New Fei1, AuthorHoehn, David1, AuthorHoffmann, Per1, AuthorHolleran, Laurena1, AuthorHoogman, Martine1, AuthorHottenga, Jouke-Jan1, AuthorIkeda, Masashi1, AuthorJanowitz, Deborah1, AuthorJansen, Iris E.1, AuthorJia, Tianye1, AuthorJockwitz, Christiane1, AuthorKanai, Ryota1, AuthorKarama, Sherif1, AuthorKasperaviciute, Dalia1, AuthorKaufmann, Tobias1, AuthorKelly, Sinead1, AuthorKikuchi, Masataka1, AuthorKlein, Marieke1, AuthorKnapp, Michael1, AuthorKnodt, Annchen R.1, AuthorKrämer, Bernd1, AuthorLam, Max1, AuthorLancaster, Thomas M.1, AuthorLee, Phil H.1, AuthorLett, Tristram A.1, AuthorLewis, Lindsay B.1, AuthorLopes-Cendes, Iscia1, AuthorLuciano, Michelle1, AuthorMacciardi, Fabio1, AuthorMarquand, Andre F.1, AuthorMathias, Samuel R.1, AuthorMelzer, Tracy R.1, AuthorMilaneschi, Yuri1, AuthorMirza-Schreiber, Nazanin1, AuthorMoreira, Jose C. V.1, AuthorMühleisen, Thomas W.1, AuthorMüller-Myhsok, Bertram1, AuthorNajt, Pablo1, AuthorNakahara, Soichiro1, AuthorNho, Kwangsik1, AuthorOlde Loohuis, Loes M.1, AuthorOrfanos, Dimitri Papadopoulos1, AuthorPearson, John F.1, AuthorPitcher, Toni L.1, AuthorPütz, Benno1, AuthorQuidé, Yann1, AuthorRagothaman, Anjanibhargavi1, AuthorRashid, Faisal M.1, AuthorReay, William R.1, AuthorRedlich, Ronny1, AuthorReinbold, Céline S.1, AuthorRepple, Jonathan1, AuthorRichard, Geneviève1, AuthorRiedel, Brandalyn C.1, AuthorRisacher, Shannon L.1, AuthorRocha, Cristiane S.1, AuthorMota, Nina Roth1, AuthorSalminen, Lauren1, AuthorSaremi, Arvin1, AuthorSaykin, Andrew J.1, AuthorSchlag, Fenja1, AuthorSchmaal, Lianne1, AuthorSchofield, Peter R.1, AuthorSecolin, Rodrigo1, AuthorShapland, Chin Yang1, AuthorShen, Li1, AuthorShin, Jean1, AuthorShumskaya, Elena1, AuthorSønderby, Ida E.1, AuthorSprooten, Emma1, AuthorTansey, Katherine E.1, AuthorTeumer, Alexander1, AuthorThalamuthu, Anbupalam1, AuthorTordesillas-Gutiérrez, Diana1, AuthorTurner, Jessica A.1, AuthorUhlmann, Anne1, AuthorVallerga, Costanza Ludovica1, Authorvan der Meer, Dennis1, Authorvan Donkelaar, Marjolein M. J.1, Authorvan Eijk, Liza1, Authorvan Erp, Theo G. M.1, Authorvan Haren, Neeltje E. M.1, Authorvan Rooij, Daan1, Authorvan Tol, Marie-José1, AuthorVeldink, Jan H.1, AuthorVerhoef, Ellen1, AuthorWalton, Esther1, AuthorWang, Mingyuan1, AuthorWang, Yunpeng1, AuthorWardlaw, Joanna M.1, AuthorWen, Wei1, AuthorWestlye, Lars T.1, AuthorWhelan, Christopher D.1, AuthorWitt, Stephanie H.1, AuthorWittfeld, Katharina1, AuthorWolf, Christiane1, AuthorWolfers, Thomas1, AuthorWu, Jing Qin1, AuthorYasuda, Clarissa L.1, AuthorZaremba, Dario1, AuthorZhang, Zuo1, AuthorZwiers, Marcel P.1, AuthorArtiges, Eric1, AuthorAssareh, Amelia A.1, AuthorAyesa-Arriola, Rosa1, AuthorBelger, Aysenil1, AuthorBrandt, Christine L.1, AuthorBrown, Gregory G.1, AuthorCichon, Sven1, AuthorCurran, Joanne E.1, AuthorDavies, Gareth E.1, AuthorDegenhardt, Franziska1, AuthorDennis, Michelle F.1, AuthorDietsche, Bruno1, AuthorDjurovic, Srdjan1, AuthorDoherty, Colin P.1, AuthorEspiritu, Ryan1, AuthorGarijo, Daniel1, AuthorGil, Yolanda1, AuthorGowland, Penny A.1, AuthorGreen, Robert C.1, AuthorHäusler, Alexander N.1, AuthorHeindel, Walter1, AuthorHo, Beng-Choon1, AuthorHoffmann, Wolfgang U.1, AuthorHolsboer, Florian1, AuthorHomuth, Georg1, AuthorHosten, Norbert1, AuthorJack, Clifford R.1, AuthorJang, MiHyun1, AuthorJansen, Andreas1, AuthorKimbrel, Nathan A.1, AuthorKolskår, Knut1, AuthorKoops, Sanne1, AuthorKrug, Axel1, AuthorLim, Kelvin O.1, AuthorLuykx, Jurjen J.1, AuthorMathalon, Daniel H.1, AuthorMather, Karen A.1, AuthorMattay, Venkata S.1, AuthorMatthews, Sarah1, AuthorMayoral Van Son, Jaqueline1, AuthorMcEwen, Sarah C.1, AuthorMelle, Ingrid1, AuthorMorris, Derek W.1, AuthorMueller, Bryon A.1, AuthorNauck, Matthias1, AuthorNordvik, Jan E.1, AuthorNöthen, Markus M.1, AuthorO’Leary, Daniel S.1, AuthorOpel, Nils1, AuthorMartinot, Marie-Laure Paillère1, AuthorPike, G. Bruce1, AuthorPreda, Adrian1, AuthorQuinlan, Erin B.1, AuthorRasser, Paul E.1, AuthorRatnakar, Varun1, AuthorReppermund, Simone1, AuthorSteen, Vidar M.1, AuthorTooney, Paul A.1, AuthorTorres, Fábio R.1, AuthorVeltman, Dick J.1, AuthorVoyvodic, James T.1, AuthorWhelan, Robert1, AuthorWhite, Tonya1, AuthorYamamori, Hidenaga1, AuthorAdams, Hieab H. H.1, AuthorBis, Joshua C.1, AuthorDebette, Stephanie1, AuthorDecarli, Charles1, AuthorFornage, Myriam1, AuthorGudnason, Vilmundur1, AuthorHofer, Edith1, AuthorIkram, M. Arfan1, AuthorLauner, Lenore1, AuthorLongstreth, W. T.1, AuthorLopez, Oscar L.1, AuthorMazoyer, Bernard1, AuthorMosley, Thomas H.1, AuthorRoshchupkin, Gennady V.1, AuthorSatizabal, Claudia L.1, AuthorSchmidt, Reinhold1, AuthorSeshadri, Sudha1, AuthorYang, Qiong1, AuthorAlvim, Marina K. M.1, AuthorAmes, David1, AuthorAnderson, Tim J.1, AuthorAndreassen, Ole A.1, AuthorArias-Vasquez, Alejandro1, AuthorBastin, Mark E.1, AuthorBaune, Bernhard T.1, AuthorBeckham, Jean C.1, AuthorBlangero, John1, AuthorBoomsma, Dorret I.1, AuthorBrodaty, Henry1, AuthorBrunner, Han G.1, AuthorBuckner, Randy L.1, AuthorBuitelaar, Jan K.1, AuthorBustillo, Juan R.1, AuthorCahn, Wiepke1, AuthorCairns, Murray J.1, AuthorCalhoun, Vince1, AuthorCarr, Vaughan J.1, AuthorCaseras, Xavier1, AuthorCaspers, Svenja1, AuthorCavalleri, Gianpiero L.1, AuthorCendes, Fernando1, AuthorCorvin, Aiden1, AuthorCrespo-Facorro, Benedicto1, AuthorDalrymple-Alford, John C.1, AuthorDannlowski, Udo1, Authorde Geus, Eco J. C.1, AuthorDeary, Ian J.1, AuthorDelanty, Norman1, AuthorDepondt, Chantal1, AuthorDesrivières, Sylvane1, AuthorDonohoe, Gary1, AuthorEspeseth, Thomas1, AuthorFernández, Guillén1, AuthorFisher, Simon E.1, AuthorFlor, Herta1, AuthorForstner, Andreas J.1, AuthorFrancks, Clyde1, AuthorFranke, Barbara1, AuthorGlahn, David C.1, AuthorGollub, Randy L.1, AuthorGrabe, Hans J.1, AuthorGruber, Oliver1, AuthorHåberg, Asta K.1, AuthorHariri, Ahmad R.1, AuthorHartman, Catharina A.1, AuthorHashimoto, Ryota1, AuthorHeinz, Andreas1, AuthorHenskens, Frans A.1, AuthorHillegers, Manon H. J.1, AuthorHoekstra, Pieter J.1, AuthorHolmes, Avram J.1, AuthorHong, L. Elliot1, AuthorHopkins, William D.1, AuthorHulshoff Pol, Hilleke E.1, AuthorJernigan, Terry L.1, AuthorJönsson, Erik G.1, AuthorKahn, René S.1, AuthorKennedy, Martin A.1, AuthorKircher, Tilo T. J.1, AuthorKochunov, Peter1, AuthorKwok, John B. J.1, AuthorLe Hellard, Stephanie1, AuthorLoughland, Carmel M.1, AuthorMartin, Nicholas G.1, AuthorMartinot, Jean-Luc1, AuthorMcDonald, Colm1, AuthorMcMahon, Katie L.1, AuthorMeyer-Lindenberg, Andreas1, AuthorMichie, Patricia T.1, AuthorMorey, Rajendra A.1, AuthorMowry, Bryan1, AuthorNyberg, Lars1, AuthorOosterlaan, Jaap1, AuthorOphoff, Roel A.1, AuthorPantelis, Christos1, AuthorPaus, Tomas1, AuthorPausova, Zdenka1, AuthorPenninx, Brenda W. J. H.1, AuthorPolderman, Tinca J. C.1, AuthorPosthuma, Danielle1, AuthorRietschel, Marcella1, AuthorRoffman, Joshua L.1, AuthorRowland, Laura M.1, AuthorSachdev, Perminder S.1, AuthorSämann, Philipp G.1, AuthorSchall, Ulrich1, AuthorSchumann, Gunter1, AuthorScott, Rodney J.1, AuthorSim, Kang1, AuthorSisodiya, Sanjay M.1, AuthorSmoller, Jordan W.1, AuthorSommer, Iris E.1, AuthorSt Pourcain, Beate1, AuthorStein, Dan J.1, AuthorToga, Arthur W.1, AuthorTrollor, Julian N.1, AuthorVan der Wee, Nic J. A.1, Authorvan ’t Ent, Dennis1, AuthorVölzke, Henry1, AuthorWalter, Henrik1, AuthorWeber, Bernd1, AuthorWeinberger, Daniel R.1, AuthorWright, Margaret J.1, AuthorZhou, Juan1, AuthorStein, Jason L.1, AuthorThompson, Paul M.1, AuthorMedland, Sarah E.1, AuthorEnhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group, Author              Villringer, Arno2, Author                  more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.

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Language(s): eng - English
 Dates: 2019-07-162020-02-102020-03-20
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/science.aay6690
PMID: 32193296
PMC: PMC7295264
 Degree: -

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Funding organization : Kavli Foundation
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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 367 (6484) Sequence Number: eaay6690 Start / End Page: - Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1