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  The developmental trajectory of functional excitation‐inhibition balance relates to language abilities in autistic and allistic children

Plueckebaum, H., Meyer, L., Beck, A., & Menn, K. (2023). The developmental trajectory of functional excitation‐inhibition balance relates to language abilities in autistic and allistic children. Autism Research, 16(9), 1681-1692. doi:10.1002/aur.2992.

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 Creators:
Plueckebaum, Hannah1, 2, Author
Meyer, Lars1, 3, Author                 
Beck, Ann‐Kathrin2, Author
Menn, Katharina1, 4, 5, Author                 
Affiliations:
1Max Planck Research Group Language Cycles, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025666              
2Center for Cognitive Science, TU Kaiserslautern, Germany, ou_persistent22              
3Department of Phoniatrics and Pedaudiology, Münster University, Germany, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
5International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              

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Free keywords: Autism; Autism symptoms; Critical brain dynamics; Excitation-inhibition ratio; Language development; Long-range temporal correlations; Neural oscillations
 Abstract: Autism is a neurodevelopmental condition that has been related to an overall imbalance between the brain's excitatory (E) and inhibitory (I) systems. Such an EI imbalance can lead to structural and functional cortical deviances and thus alter information processing in the brain, ultimately giving rise to autism traits. However, the developmental trajectory of EI imbalances across childhood and adolescence has not been investigated yet. Therefore, its relationship to autism traits is not well understood. In the present study, we determined a functional measure of the EI balance (f-EIB) from resting-state electrophysiological recordings for a final sample of 92 autistic children from 6 to 17 years of age and 100 allistic (i.e., non-autistic) children matched by age, sex, and nonverbal-IQ. We related the developmental trajectory of f-EIB to behavioral assessments of autism traits as well as language ability. Our results revealed differential EI trajectories for autistic compared to allistic children. Importantly, the developmental trajectory of f-EIB values related to individual language ability. In particular, elevated excitability in late childhood and early adolescence was linked to decreased listening comprehension. Our findings provide evidence against a general EI imbalance in autistic children when correcting for non-verbal IQ. Instead, we show that the developmental trajectory of EI balance shares variance with autism trait development at a specific age range. This is consistent with the proposal that the late development of inhibitory brain activity is a key substrate of autism traits.

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Language(s): eng - English
 Dates: 2023-03-222023-07-062023-07-262023-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/aur.2992
Other: epub 2023
PMID: 37493078
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Funding organization : Max-Planck-Gesellschaft
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Funding organization : Ministeriums für Wissenschaft, Weiterbildung und Kultur, Rheinland-Pfalz
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Funding organization : Projekt DEAL

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Title: Autism Research
Source Genre: Journal
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Publ. Info: Hoboken, NJ, USA : Wiley
Pages: - Volume / Issue: 16 (9) Sequence Number: - Start / End Page: 1681 - 1692 Identifier: ISSN: 1939-3792
CoNE: https://pure.mpg.de/cone/journals/resource/1939-3792