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  Circadian and homeostatic modulation of human retinal function: A pre-registered study protocol

Heinrichs, H., & Spitschan, M. (2023). Circadian and homeostatic modulation of human retinal function: A pre-registered study protocol. Poster presented at 65th Conference of Experimental Psychologists: TeaP 2023: Tagung experimentell arbeitender Psycholog:innen, Trier, Germany.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-8FB7-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-8FB9-2
Genre: Poster

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https://www.psycharchives.org/en/item/530c1dbe-d94e-4476-8d11-fba4e9021466 (Abstract)
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 Creators:
Heinrichs, HS1, Author                 
Spitschan, M1, Author                 
Affiliations:
1Research Group Translational Sensory and Circadian Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3360460              

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 Abstract: Background Daily variation in our physiology and behavior at the 24-hour scale are governed by two independent processes, an endogenous circadian rhythm and a sleep homeostat. Through the retinohypothalamic pathway, which carries information from the retina, the hypothalamus responds to light in order to synchronize the internal circadian rhythm to the external environment, rendering visual input an important circadian signal. The link between visual signals and the circadian system may be bi-directional, i.e., the sensitivity of the visual system to light may be modulated by the circadian clock itself. Methods Building upon converging evidence for a of time-of day dependency in image- forming (e.g. luminance perception) and non image-forming functions (e.g. pupillary light response), we will disentangle circadian and homeostatic effects on early stages of visual processing in a pre-registered study. We will use the constant routine protocol spanning 34 hours with healthy participants (n = 24) staying awake in a constant dim light environment, and providing repeated measures of ocular structures and functional mechanisms in 3-hour intervals. Our focus will be on assessing photoreceptor sensitivity using silent-substitution pupillometry, and characterising post-receptoral retinal mechanisms underlying luminance and color perception using psychophysical threshold measurements. To estimate circadian phase, we will collect circadian biomarkers, including salivary melatonin and core body temperature. Relevance This study will characterize the circadian and homeostatic influence on retinal mechanisms, informing how daily variations in physiology influence how we process light in the environment.

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 Dates: 2023-06
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.23668/psycharchives.12945
 Degree: -

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Title: 65th Conference of Experimental Psychologists: TeaP 2023: Tagung experimentell arbeitender Psycholog:innen
Place of Event: Trier, Germany
Start-/End Date: 2023-03-26 - 2023-03-29

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Title: Abstracts of the 65th TeaP
Source Genre: Proceedings
 Creator(s):
Merz, S, Editor
Frings, C, Editor
Leuchtenberg, B, Editor
Moeller, B, Editor
Neumann, R, Editor
Pastötter, B, Editor
Pingen, L, Editor
Schui, G, Editor
Affiliations:
-
Publ. Info: Trier, Germany : ZPID
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 147 - 148 Identifier: -