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Zusammenfassung:
Like many species of teleost fish, the gymnotiform Apteronotus leptorhynchus displays a high degree of proliferative activity in a large number of brain regions during adulthood. One of these regions is the central posterior/prepacemaker nucleus (CP/PPn) in the diencephalon. By applying in situ techniques for the detection of DNA fragmentation, a feature characteristic of apoptotic cells, we show in the present study that the high proliferative activity in the CP/PPn is counterbalanced by programmed cell death. Most of the apoptotic events occur in the ventricular and subventricular zones of this thalamic complex, where the generation of the cells and their differentiation into neurons take place. The demonstration of apoptosis in the CP/PPn provides strong evidence against the hypothesis that animals in which neurogenesis continues beyond embryonic stages of development lack cell death.
