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  Cholinesterases and peanut agglutinin binding related to cell proliferation and axonal growth in embryonic chick limbs

Alber, R., Sporns, O., Weikert, T., Willbold, E., & Layer, P. (1994). Cholinesterases and peanut agglutinin binding related to cell proliferation and axonal growth in embryonic chick limbs. Anatomy and Embryology, 190(5), 429-438. doi:10.1007/BF00235489.

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Alber, R1, Autor           
Sporns, O2, Autor                 
Weikert, T1, Autor           
Willbold, E1, Autor                 
Layer, PG1, Autor           
Affiliations:
1Department Molecular Biology Gierer, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3404872              
2Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375716              

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 Zusammenfassung: Embryonic cholinesterases are assigned important functions during morphogenesis. Here we describe the expression of butyrylcholinesterase and acetylcholinesterase, and the binding of peanut agglutinin, and relate the results to mitotic activity in chick wing and leg buds from embryonic day 4 to embryonic day 9. During early stages, butyrylcholinesterase is elevated in cells under the apical ectodermal ridge and around invading motoraxons, while acetylcholinesterase is found in the chondrogenic core, on motoraxons and along the ectoderm. Peanut agglutinin binds to the apical ectodermal ridge and most prominently to the chondrogenic core. Measurements of thymidine incorporation and enzyme activities were consistent with our histological findings. Butyrylcholinesterase is concentrated near proliferative zones and periods, while acetylcholinesterase is associated with low proliferative activity. At late stages of limb development, acetylcholinesterase is concentrated in muscles and nonexistent within bones, while butyrylcholinesterase shows an inverse pattern. Thus, as in other systems, in limb formation butyrylcholinesterase is a transmitotic marker preceding differentiation, acetylcholinesterase is found on navigating axons, while peanut agglutinin appears in non-invaded regions. These data suggest roles for cholinesterases as positive regulators and peanut-agglutinin-binding proteins as negative regulators of neural differentiation.

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 Datum: 1994-11
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: DOI: 10.1007/BF00235489
PMID: 7887493
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Titel: Anatomy and Embryology
  Andere : Anat. Embryol.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Berlin : Springer International
Seiten: - Band / Heft: 190 (5) Artikelnummer: - Start- / Endseite: 429 - 438 Identifikator: ISSN: 0340-2061
CoNE: https://pure.mpg.de/cone/journals/resource/954927579056