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  Lack of myelin improves axon survival in inflammatory lesions in the CNS

Nave, K.-A., & Stassart, R. M. (2023). Lack of myelin improves axon survival in inflammatory lesions in the CNS. Nature Neuroscience, 26, 1145-1146. doi:10.1038/s41593-023-01372-x.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-B909-9 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-B90A-8
Genre: Journal Article

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s41593-023-01372-x.pdf (Publisher version), 2MB
 
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 Creators:
Nave, Klaus-Armin1, Author           
Stassart, Ruth M.1, Author           
Affiliations:
1Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350301              

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 Abstract: By studying axonal pathology in human multiple sclerosis and its models, we observed that myelin ensheathment itself can be detrimental for axonal survival. We hypothesize that oligodendroglial support is disrupted under inflammatory conditions, with the most severe consequences for the axons that remain physically isolated from the extracellular milieu by myelin.

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Language(s): eng - English
 Dates: 2023-06-29
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41593-023-01372-x
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 26 Sequence Number: - Start / End Page: 1145 - 1146 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931