非表示:
キーワード:
Delignified wood, Composites, Hydrogel, Soft materials, Mechanical gradient, Cell alignment
要旨:
Delignified wood (DW) offers a versatile platform for the manufacturing of composites, with material properties ranging from stiff to soft and flexible by preserving the preferential fiber directionality of natural wood through a structure-retaining production process. This study presents a facile method for fabricating anisotropic and mechanically tunable DW-hydrogel composites. These composites were produced by infiltrating delignified spruce wood with an aqueous gelatin solution followed by chemical crosslinking. The mechanical properties could be modulated across a broad strength and stiffness range (1.2–18.3 MPa and 170–1455 MPa, respectively) by varying the crosslinking time. The diffusion-led crosslinking further allowed to manufacture mechanically graded structures. The resulting uniaxial, tubular structure of the anisotropic DW-hydrogel composite enabled the alignment of murine fibroblasts in vitro, which could be utilized in future studies on potential applications in tissue engineering.
