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  Biomolecular actuators for genetically selective acoustic manipulation of cells

Wu, D., Baresch, D., Cook, C., Ma, Z., Duan, M., Malounda, D., et al. (2023). Biomolecular actuators for genetically selective acoustic manipulation of cells. Science Advances, 9(8): eadd9186, pp. 1-16. doi:10.1126/sciadv.add9186.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-AF96-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-AFA9-0
Genre: Journal Article

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 Creators:
Wu, Di , Author
Baresch, Diego, Author
Cook, Colin, Author
Ma, Zhichao, Author           
Duan, Mengtong, Author
Malounda, Dina, Author
Maresca, David, Author
Abundo, Maria P., Author
Lee, Justin, Author
Shivaei, Shirin, Author
Mittelstein, David R., Author
Qiu, Tian, Author
Fischer, Peer1, Author                 
Shapiro, Mikhail G., Author
Affiliations:
1Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: The ability to physically manipulate specific cells is critical for the fields of biomedicine, synthetic biology, and living materials. Ultrasound has the ability to manipulate cells with high spatiotemporal precision via acoustic radiation force (ARF). However, because most cells have similar acoustic properties, this capability is disconnected from cellular genetic programs. Here, we show that gas vesicles (GVs)-a unique class of gas-filled protein nanostructures-can serve as genetically encodable actuators for selective acoustic manipulation. Because of their lower density and higher compressibility relative to water, GVs experience strong ARF with opposite polarity to most other materials. When expressed inside cells, GVs invert the cells' acoustic contrast and amplify the magnitude of their ARF, allowing the cells to be selectively manipulated with sound waves based on their genotype. GVs provide a direct link between gene expression and acoustomechanical actuation, opening a paradigm for selective cellular control in a broad range of contexts.

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Language(s): eng - English
 Dates: 2022-08-082023-01-222023-02-22
 Publication Status: Published online
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/sciadv.add9186
URI: https://pubmed.ncbi.nlm.nih.gov/36812320/
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946353/
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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
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Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 9 (8) Sequence Number: eadd9186 Start / End Page: 1 - 16 Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548