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  Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction

Kim, M., Serwa, R. A., Samluk, L., Suppanz, I., Kodroń, A., Stępkowski, T. M., et al. (2023). Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction. Nature Communications, 14: 4092. doi:10.1038/s41467-023-39642-8.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-B337-B Version Permalink: https://hdl.handle.net/21.11116/0000-000D-B338-A
Genre: Journal Article

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10.1038_s41467-023-39642-8.pdf (Publisher version), 3MB
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 Creators:
Kim, Minji1, Author
Serwa, Remigiusz A1, Author
Samluk, Lukasz1, Author
Suppanz, Ida2, Author
Kodroń, Agata1, Author
Stępkowski, Tomasz M1, Author
Elancheliyan, Praveenraj1, Author
Tsegaye, Biniyam1, Author
Oeljeklaus, Silke1, Author
Wasilewski, Michal1, Author
Warscheid, Bettina1, Author
Chacinska, Agnieszka1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: Chaperones, Mitochondria, Proteasome, Protein aggregation
 Abstract: Perturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an important role in neurodegenerative diseases, however, the interplay between these two phenomena remains unclear. Mitochondrial dysfunction leads to a delay in mitochondrial protein import, causing accumulation of non-imported mitochondrial proteins in the cytosol and challenging proteostasis. Cells respond by increasing proteasome activity and molecular chaperones in yeast and C. elegans. Here, we demonstrate that in human cells mitochondrial dysfunction leads to the upregulation of a chaperone HSPB1 and, interestingly, an immunoproteasome-specific subunit PSMB9. Moreover, PSMB9 expression is dependent on the translation elongation factor EEF1A2. These mechanisms constitute a defense response to preserve cellular proteostasis under mitochondrial stress. Our findings define a mode of proteasomal activation through the change in proteasome composition driven by EEF1A2 and its spatial regulation, and are useful to formulate therapies to prevent neurodegenerative diseases.

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Language(s): eng - English
 Dates: 2023-07-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-023-39642-8
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 14 Sequence Number: 4092 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723