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  Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Schäffner, E., Bosch-Queralt, M., Edgar, J. M., Lehning, M., Strauß, J., Fleischer, N., et al. (2023). Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. Nature Neuroscience, 26, 1218-1228. doi:10.1038/s41593-023-01366-9.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-B763-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-E141-B
Genre: Journal Article

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s41593-023-01366-9.pdf (Publisher version), 11MB
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 Creators:
Schäffner, Erik1, Author           
Bosch-Queralt, Mar, Author
Edgar, Julia M.1, Author           
Lehning, Maria, Author
Strauß, Judith, Author
Fleischer, Niko, Author
Kungl, Theresa, Author
Wieghofer, Peter, Author
Berghoff, Stefan A.1, Author           
Reinert, Tilo, Author
Krueger, Martin, Author
Morawski, Markus, Author
Möbius, Wiebke1, Author           
Barrantes-Freer, Alonso, Author
Stieler, Jens, Author
Sun, Ting1, Author           
Saher, Gesine1, Author           
Schwab, Markus H., Author
Wrede, Christoph, Author
Frosch, Maximilian, Author
Prinz, Marco, AuthorReich, Daniel S., AuthorFlügel, Alexander, AuthorStadelmann, Christine, AuthorFledrich, Robert1, Author           Nave, Klaus-Armin1, Author           Stassart, Ruth M.1, Author            more..
Affiliations:
1Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, Göttingen, DE, ou_3350301              

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 Abstract: Axonal degeneration determines the clinical outcome of multiple sclerosis and is thought to result from exposure of denuded axons to immune-mediated damage. Therefore, myelin is widely considered to be a protective structure for axons in multiple sclerosis. Myelinated axons also depend on oligodendrocytes, which provide metabolic and structural support to the axonal compartment. Given that axonal pathology in multiple sclerosis is already visible at early disease stages, before overt demyelination, we reasoned that autoimmune inflammation may disrupt oligodendroglial support mechanisms and hence primarily affect axons insulated by myelin. Here, we studied axonal pathology as a function of myelination in human multiple sclerosis and mouse models of autoimmune encephalomyelitis with genetically altered myelination. We demonstrate that myelin ensheathment itself becomes detrimental for axonal survival and increases the risk of axons degenerating in an autoimmune environment. This challenges the view of myelin as a solely protective structure and suggests that axonal dependence on oligodendroglial support can become fatal when myelin is under inflammatory attack.

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Language(s): eng - English
 Dates: 2023-06-292023-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41593-023-01366-9
 Degree: -

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Project name : S.A.B. was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; SFB TRR 274/1 2020 A06–408885537). M.B.Q. was supported by a DFG Walter-Benjamin Position (BO 6252/1-1). J.M.E. was supported by Grant 127 from the UK MS Society. R.F. was supported by a DFG Emmy-Noether fellowship (FL 1025/1-1). Ju.S. and A.F. were funded by DFG grant FL 377/4-1, and A.F. was funded by DFG grant SFB TRR 274/1 2020 A03–408885537 and by a European Research Council (ERC) Advanced Grant (101021345, T-Neuron). K.A.N. was supported by an ERC Advanced Grant, the DFG (SFB TRR 274) and the Adelson Medical Research Foundation (AMRF). D.S.R. was supported by the Intramural Research Program of NINDS and by the AMRF. E.S. was supported by a Boehringer Ingelheim Foundation travel grant. C.S. was supported by the DFG under Germany’s Excellence Strategy (EXC 2067/1-390729940), the SFB TRR 274/1 2020 A03–408885537 (B01) and the DFG grant STA 1389/5-1. R.M.S. was supported by an ERC Starting Grant (948857, AxoMyoGlia) and DFG grant STA 1728/1-1. R.F. and R.M.S. were supported by a DFG grant in SFB 1052, 209933838, subproject C10, and by the German Ministry of Education and Research (BMBF) FKZ 01KC2003B and 01EJ2203C.
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Funding organization : -
Project name : T-Neuron
Grant ID : 101021345
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : AxoMyoGlia
Grant ID : 948857
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
 Creator(s):
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 26 Sequence Number: - Start / End Page: 1218 - 1228 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931