English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

González-Peñas, J., De Hoyos, L., Díaz-Caneja, C. M., Andreu-Bernabeu, Á., Stella, C., Gurriarán, X., et al. (2023). Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy. Scientific Reports, 13: 15500. doi:10.1038/s41598-023-42578-0.

Item is

Files

show Files
hide Files
:
Gonzalez-Penas_etal_2023_Recent natural.....pdf (Publisher version), 3MB
Name:
Gonzalez-Penas_etal_2023_Recent natural.....pdf
Description:
-
OA-Status:
Gold
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
2023
Copyright Info:
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
:
gonzalez-Penas_etal_2023suppl1_Recent natural.....pdf (Supplementary material), 537KB
Name:
supplementary figures
Description:
-
OA-Status:
Gold
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
gonzalez-Penas_etal_2023suppl2_Recent natural.....xlsx (Supplementary material), 11MB
Name:
supplementary information
Description:
-
OA-Status:
Gold
Visibility:
Public
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
González-Peñas, Javier1, 2, 3, Author
De Hoyos, Lucía4, 5, 6, Author           
Díaz-Caneja, Covadonga M.1, 2, 3, 7, Author
Andreu-Bernabeu, Álvaro1, 2, 7, Author
Stella, Carol1, 2, Author
Gurriarán, Xaquín1, 2, Author
Fañanás, Lourdes3, 8, Author
Bobes, Julio3, 9, Author
González-Pinto, Ana3, 10, Author
Crespo-Facorro, Benedicto3, 11, Author
Martorell, Lourdes3, 12, Author
Vilella, Elisabet3, 12, Author
Muntané, Gerard3, 12, Author
Molto, María Dolores3, 13, Author
Gonzalez-Piqueras, Jose Carlos3, 13, 14, Author
Parellada, Mara1, 2, 3, 7, Author
Arango, Celso1, 2, 3, 7, Author
Costas, Javier15, Author
Affiliations:
1Hospital General Universitario Gregorio Marañón, Madrid, Spain, ou_persistent22              
2Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain, ou_persistent22              
3CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain , ou_persistent22              
4Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
5Population genetics of human communication, MPI for Psycholinguistics, Max Planck Society, ou_2579694              
6International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_1119545              
7Universidad Complutense, Madrid, Spain, ou_persistent22              
8University of Barcelona, Barcelona, Spain, ou_persistent22              
9Universidad de Oviedo, Oviedo, Spain, ou_persistent22              
10University of the Basque Country, Vitoria, Spain, ou_persistent22              
11Universidad de Sevilla, Sevilla, Spain, ou_persistent22              
12Universitat Rovira I Virgili, Reus, Spain, ou_persistent22              
13Universitat de València, Valencia, Spain, ou_persistent22              
14Fundación Investigación Hospital Clínico de Valencia, Valencia, Spain, ou_persistent22              
15Instituto de Investigación Sanitaria (IDIS) de Santiago de Compostela, Santiago de Compostela, Spain, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Schizophrenia is a debilitating psychiatric disorder associated with a reduced fertility and decreased life expectancy, yet common predisposing variation substantially contributes to the onset of the disorder, which poses an evolutionary paradox. Previous research has suggested balanced selection, a mechanism by which schizophrenia risk alleles could also provide advantages under certain environments, as a reliable explanation. However, recent studies have shown strong evidence against a positive selection of predisposing loci. Furthermore, evolutionary pressures on schizophrenia risk alleles could have changed throughout human history as new environments emerged. Here in this study, we used 1000 Genomes Project data to explore the relationship between schizophrenia predisposing loci and recent natural selection (RNS) signatures after the human diaspora out of Africa around 100,000 years ago on a genome-wide scale. We found evidence for significant enrichment of RNS markers in derived alleles arisen during human evolution conferring protection to schizophrenia. Moreover, both partitioned heritability and gene set enrichment analyses of mapped genes from schizophrenia predisposing loci subject to RNS revealed a lower involvement in brain and neuronal related functions compared to those not subject to RNS. Taken together, our results suggest non-antagonistic pleiotropy as a likely mechanism behind RNS that could explain the persistence of schizophrenia common predisposing variation in human populations due to its association to other non-psychiatric phenotypes.

Details

show
hide
Language(s): eng - English
 Dates: 2023-09-19
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-023-42578-0
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 13 Sequence Number: 15500 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322