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  Expanding the function of oligodendrocytes to brain energy metabolism

Nave, K.-A., Asadollahi, E., & Sasmita, A. O. (2023). Expanding the function of oligodendrocytes to brain energy metabolism. Current Opinion in Neurobiology, 83: 102782. doi:10.1016/j.conb.2023.102782.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-BD49-D Version Permalink: https://hdl.handle.net/21.11116/0000-000D-E13D-1
Genre: Journal Article

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1-s2.0-S0959438823001071-main.pdf (Publisher version), 1012KB
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Version of Record 12 September 2023
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 Creators:
Nave, Klaus-Armin1, Author           
Asadollahi, Ebrahim1, Author           
Sasmita, Andrew O.1, Author           
Affiliations:
1Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350301              

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 Abstract: Oligodendrocytes are best known for wrapping myelin, a unique specialization that enables energy-efficient and fast axonal impulse propagation in white matter tracts and fibers of the cortical circuitry. However, myelinating oligodendrocytes have additional metabolic functions that are only gradually understood, including the regulated release of pyruvate/lactate and extracellular vesicles, both of which are in support of the axonal energy balance. The axon-supportive functions of glial cells are older than myelin in nervous system evolution and implicate oligodendrocyte dysfunction and loss of myelin integrity as a risk factor for progressive neurodegeneration in brain diseases.

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Language(s): eng - English
 Dates: 2023-09-122023-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.conb.2023.102782
 Degree: -

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Project name : KAN's research was supported by the Max Planck Society and grants from the European Research Council (AxoGLIA, MyeliNANO), Deutsche Forschungsgemeinschaft (TRR274) and the Adelson Medical Research Foundation (AMRF).
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Funding program : -
Funding organization : -
Project name : AxoGLIA
Grant ID : 269020
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : MyeliNANO
Grant ID : 671048
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: Current Opinion in Neurobiology
  Other : Curr. Opin.Neurobiol.
Source Genre: Journal
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Publ. Info: New York, NY : Elsevier Current Trends
Pages: - Volume / Issue: 83 Sequence Number: 102782 Start / End Page: - Identifier: ISSN: 0959-4388
CoNE: https://pure.mpg.de/cone/journals/resource/954925578066