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ELECTRON TOMOGRAPHY; ARCHITECTUREBiochemistry & Molecular Biology; Biophysics;
Abstract:
Cryo-electron tomography allows to visualize the molecular architecture of pristinely preserved cellular landscapes in three dimensions. In favorable scenarios, macromolecular and supramolecular structures can be determined in situ with near-atomic resolution. The aim of visual proteomics is the parallel identification and annotation of all densities in the tomograms allowing for a comprehensive description of the molecular sociology of cells. (c) 2022 Published by Elsevier Inc.
