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要旨:
The oral microbiome of human populations worldwide includes commonly-shared core species whose dominant strains differ between populations. The origin of population-specific oral strains is unclear. To address this question, we analysed paired saliva metagenomes and human genomes for 538 adult women living in Germany, Vietnam and Gabon. Between countries, a parallel evolutionary history was evident for humans and over 88% of the assessed common saliva microbes (23/26 taxa). A subset of the common saliva species displayed codiversification even within countries. In addition, species that exhibited the most pronounced codiversification have independently developed characteristics linked to host dependency, including reduced genomes sizes, sensitivity to oxygen and antibiotics, and genome reduction of genes associated with replication, recombination, repair and cell motility. Our findings suggest a shared evolutionary history between humans and oral microbiota.
