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Abstract:
Introduction: Chemical Exchange Saturation Transfer (CEST) imaging has emerged as a promising imaging modality in acute ischemic stroke (AIS). It utilizes the apparent chemical exchange between protons belonging to the proton pool of specific metabolites and protons of the bulk water pool. This allows for pH-dependent image contrasts offering an insight into the metabolic state of affected areas. In this first study at 7 T in AIS using multi-pool CEST, we aim to quantify acidity changes to further reveal pathophysiological pro- cesses in the ischemic brain parenchyma and possibly aid individual outcome prediction.
