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  A DNA turbine powered by a transmembrane potential across a nanopore

Shi, X., Pumm, A.-K., Maffeo, C., Kohler, F., Feigl, E., Zhao, W., et al. (2024). A DNA turbine powered by a transmembrane potential across a nanopore. Nature Nanotechnology, 19, 338-344. doi:10.1038/s41565-023-01527-8.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-D962-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-2255-B
Genre: Journal Article

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s41565-023-01527-8.pdf (Publisher version), 5MB
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 Creators:
Shi, Xin, Author
Pumm, Anna-Katharina, Author
Maffeo, Christopher, Author
Kohler, Fabian, Author
Feigl, Elija, Author
Zhao, Wenxuan, Author
Verschueren, Daniel, Author
Golestanian, Ramin1, Author                 
Aksimentiev, Aleksei, Author
Dietz, Hendrik, Author
Dekker, Cees, Author
Affiliations:
1Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2570692              

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 Abstract: Rotary motors play key roles in energy transduction, from macroscale windmills to nanoscale turbines such as ATP synthase in cells. Despite our abilities to construct engines at many scales, developing functional synthetic turbines at the nanoscale has remained challenging. Here, we experimentally demonstrate rationally designed nanoscale DNA origami turbines with three chiral blades. These DNA nanoturbines are 24–27 nm in height and diameter and can utilize transmembrane electrochemical potentials across nanopores to drive DNA bundles into sustained unidirectional rotations of up to 10 revolutions s−1. The rotation direction is set by the designed chirality of the turbine. All-atom molecular dynamics simulations show how hydrodynamic flows drive this turbine. At high salt concentrations, the rotation direction of turbines with the same chirality is reversed, which is explained by a change in the anisotropy of the electrophoretic mobility. Our artificial turbines operate autonomously in physiological conditions, converting energy from naturally abundant electrochemical potentials into mechanical work. The results open new possibilities for engineering active robotics at the nanoscale.

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Language(s): eng - English
 Dates: 2023-10-262024-03
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41565-023-01527-8
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Project name : LoopingDNA
Grant ID : 883684
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : -
Grant ID : 724261
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : the Deutsche Forschungsgemeinschaft via the Gottfried-Wilhelm-Leibniz Programme (to H.D.) and the SFB863 Project ID 111166240 TPA9 (to H.D.). A.A. and C.M. acknowledge support through the National Science Foundation (USA) under grant DMR-1827346 (to A.A.). This work has received support from the Max Planck School Matter to Life and the MaxSynBio Consortium, which are jointly funded by the Federal Ministry of Education and Research (BMBF) of Germany, and the Max Planck Society (to R.G.). Supercomputer time was provided through Leadership Resource Allocation MCB20012 on Frontera and through ACCESS allocation MCA05S028.
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Title: Nature Nanotechnology
  Other : Nat. Nanotechnol.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 19 Sequence Number: - Start / End Page: 338 - 344 Identifier: ISSN: 1748-3387
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000239770