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  Triggered contraction of self-assembled, micron-scale DNA nanotube rings

Illig, M., Jahnke, K., Weise, L. P., Scheffold, M., Mersdorf, U., Drechsler, H., et al. (2024). Triggered contraction of self-assembled, micron-scale DNA nanotube rings. Nature Communications, 15(1): 2307, pp. 1-12. doi: 10.1038/s41467-024-46339-z.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000E-0933-F Version Permalink: https://hdl.handle.net/21.11116/0000-000F-2AC4-5
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 Creators:
Illig, Maja1, Author           
Jahnke, Kevin2, Author           
Weise, Lukas P., Author
Scheffold, Marlene1, Author           
Mersdorf, Ulrike3, Author           
Drechsler, Hauke, Author
Zhang, Yixin, Author
Diez, Stefan, Author
Kierfeld, Jan, Author
Göpfrich, Kerstin2, Author           
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              
2Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
3Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction - without motor proteins - providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials.

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Language(s): eng - English
 Dates: 2023-09-132024-02-212024-03-14
 Publication Status: Published online
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-024-46339-z
URI: https://pubmed.ncbi.nlm.nih.gov/38485920/
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 15 (1) Sequence Number: 2307 Start / End Page: 1 - 12 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723