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  Is the distribution of plasmid lengths bimodal?

Dewan, I., & Uecker, H. (2024). Is the distribution of plasmid lengths bimodal? Plasmid, 129: 102721. doi:10.1016/j.plasmid.2024.102721.

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 Creators:
Dewan, Ian1, 2, Author                 
Uecker, Hildegard1, Author                 
Affiliations:
1Research Group Stochastic Evolutionary Dynamics (Uecker), Department Theoretical Biology (Traulsen), Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2640692              
2IMPRS for Evolutionary Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445639              

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Free keywords: Plasmids, Logarithmic scale, Density estimation
 Abstract: The length of a plasmid is a key property which is linked to many aspects of plasmid biology. When distributions of plasmid lengths are shown in the literature, they are usually plotted with length on a logarithmic scale. However, a quantity and its logarithm have distinct distributions which may differ considerably in shape. Mistaking the distribution of log-lengths for the distribution of lengths can therefore lead to distorted conclusions about the distribution; in particular, the distribution of log-lengths may be bimodal when the distribution of lengths is only unimodal. This particular confusion has arisen in the literature where the length distribution is often claimed to be bimodal based on examination of what is in fact the log-length distribution. While the length distribution is indeed bimodal within many bacterial families, it is not across the ensemble of all plasmids. We suggest that authors should be careful to show the plasmid length distribution, or to distinguish the two distributions, to avoid misleading inferences.

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Language(s): eng - English
 Dates: 2023-09-112024-01-242023-09-102024-01-252024-02-042024-02
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.plasmid.2024.102721
 Degree: -

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Project name : Project 3 within the Research Training Group 2501 Translational Evolutionary Research
Grant ID : 400993799
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Plasmid
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 129 Sequence Number: 102721 Start / End Page: - Identifier: ISSN: 0147-619X
CoNE: https://pure.mpg.de/cone/journals/resource/954922647089