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  Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Kadalayil, L., Alam, M. Z., White, C. H., Ghantous, A., Walton, E., Gruzieva, O., Merid, S. K., Kumar, A., Roy, R. P., Solomon, O., Huen, K., Eskenazi, B., Rzehak, P., Grote, V., Langhendries, J.-P., Verduci, E., Ferre, N., Gruszfeld, D., Gao, L., Guan, W., Zeng, X., Schisterman, E. F., Dou, J. F., Bakulski, K. M., Feinberg, J. I., Soomro, M. H., Pesce, G., Baiz, N., Isaevska, E., Plusquin, M., Vafeiadi, M., Roumeliotaki, T., Langie, S. A. S., Standaert, A., Allard, C., Perron, P., Bouchard, L., van Meel, E. R., Felix, J. F., Jaddoe, V. W. V., Yousefi, P. D., Ramlau-Hansen, C. H., Relton, C. L., Tobi, E. W., Starling, A. P., Yang, I. V., Llambrich, M., Santorelli, G., Lepeule, J., Salas, L. A., Bustamante, M., Ewart, S. L., Zhang, H., Karmaus, W., Roeder, S., Zenclussen, A. C., Jin, J., Nystad, W., Page, C. M., Magnus, M., Jima, D. D., Hoyo, C., Maguire, R. L., Kvist, T., Czamara, D., Raikkonen, K., Gong, T., Ullemar, V., Rifas-Shiman, S. L., Oken, E., Almqvist, C., Karlsson, R., Lahti, J., Murphy, S. K., Haberg, S. E., London, S., Herberth, G., Arshad, H., Sunyer, J., Grazuleviciene, R., Dabelea, D., Steegers-Theunissen, R. P. M., Nohr, E. A., Sorensen, T. I. A., Duijts, L., Hivert, M.-F., Nelen, V., Popovic, M., Kogevinas, M., Nawrot, T. S., Herceg, Z., Annesi-Maesano, I., Fallin, M. D., Yeung, E., Breton, C. V., Koletzko, B., Holland, N., Wiemels, J. L., Melen, E., Sharp, G. C., Silver, M. J., Rezwan I, F., & Holloway, J. W. (2023). Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude. CLINICAL EPIGENETICS, 15(1):. doi:10.1186/s13148-023-01542-5.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000D-DEC6-A 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-E860-1
資料種別: 学術論文

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 作成者:
Kadalayil, Latha, 著者
Alam, Md. Zahangir, 著者
White, Cory Haley, 著者
Ghantous, Akram, 著者
Walton, Esther, 著者
Gruzieva, Olena, 著者
Merid, Simon Kebede, 著者
Kumar, Ashish, 著者
Roy, Ritu P., 著者
Solomon, Olivia, 著者
Huen, Karen, 著者
Eskenazi, Brenda, 著者
Rzehak, Peter, 著者
Grote, Veit, 著者
Langhendries, Jean-Paul, 著者
Verduci, Elvira, 著者
Ferre, Natalia, 著者
Gruszfeld, Darek, 著者
Gao, Lu, 著者
Guan, Weihua, 著者
Zeng, Xuehuo, 著者Schisterman, Enrique F., 著者Dou, John F., 著者Bakulski, Kelly M., 著者Feinberg, Jason I., 著者Soomro, Munawar Hussain, 著者Pesce, Giancarlo, 著者Baiz, Nour, 著者Isaevska, Elena, 著者Plusquin, Michelle, 著者Vafeiadi, Marina, 著者Roumeliotaki, Theano, 著者Langie, Sabine A. S., 著者Standaert, Arnout, 著者Allard, Catherine, 著者Perron, Patrice, 著者Bouchard, Luigi, 著者van Meel, Evelien R., 著者Felix, Janine F., 著者Jaddoe, Vincent W. V., 著者Yousefi, Paul D., 著者Ramlau-Hansen, Cecilia H., 著者Relton, Caroline L., 著者Tobi, Elmar W., 著者Starling, Anne P., 著者Yang, Ivana V., 著者Llambrich, Maria, 著者Santorelli, Gillian, 著者Lepeule, Johanna, 著者Salas, Lucas A., 著者Bustamante, Mariona, 著者Ewart, Susan L., 著者Zhang, Hongmei, 著者Karmaus, Wilfried, 著者Roeder, Stefan, 著者Zenclussen, Ana Claudia, 著者Jin, Jianping, 著者Nystad, Wenche, 著者Page, Christian M., 著者Magnus, Maria, 著者Jima, Dereje D., 著者Hoyo, Cathrine, 著者Maguire, Rachel L., 著者Kvist, Tuomas, 著者Czamara, Darina1, 著者           Raikkonen, Katri, 著者Gong, Tong, 著者Ullemar, Vilhelmina, 著者Rifas-Shiman, Sheryl L., 著者Oken, Emily, 著者Almqvist, Catarina, 著者Karlsson, Robert, 著者Lahti, Jari, 著者Murphy, Susan K., 著者Haberg, Siri E., 著者London, Stephanie, 著者Herberth, Gunda, 著者Arshad, Hasan, 著者Sunyer, Jordi, 著者Grazuleviciene, Regina, 著者Dabelea, Dana, 著者Steegers-Theunissen, Regine P. M., 著者Nohr, Ellen A., 著者Sorensen, Thorkild I. A., 著者Duijts, Liesbeth, 著者Hivert, Marie-France, 著者Nelen, Vera, 著者Popovic, Maja, 著者Kogevinas, Manolis, 著者Nawrot, Tim S., 著者Herceg, Zdenko, 著者Annesi-Maesano, Isabella, 著者Fallin, M. Daniele, 著者Yeung, Edwina, 著者Breton, Carrie V., 著者Koletzko, Berthold, 著者Holland, Nina, 著者Wiemels, Joseph L., 著者Melen, Erik, 著者Sharp, Gemma C., 著者Silver, Matt J., 著者Rezwan I, Faisal, 著者Holloway, John W., 著者 全て表示
所属:
1Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

内容説明

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 要旨: Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear.
Methods We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1-11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points.
Results We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (>= 50 degrees N), lower (< 50 degrees N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation including asthma (LTB4R), present only at birth in the higher latitudes (>= 50 degrees N).
Conclusions In this large epigenome-wide meta-analysis study, we provide evidence for (i) associations between DNAm and season of birth that are unique for the seasons of the year (temporal effect) and (ii) latitude-dependent variations in the seasonal associations (spatial effect). DNAm could play a role in the molecular mechanisms underlying the effect of birth season on adult health outcomes.

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 日付: 2023
 出版の状態: オンラインで出版済み
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 識別子（DOI, ISBNなど）: ISI: 001068850100001
DOI: 10.1186/s13148-023-01542-5
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出版物 1

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出版物名: CLINICAL EPIGENETICS
種別: 学術雑誌
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出版社, 出版地: -
ページ: - 巻号: 15 (1) 通巻号: 148 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 1868-7075