English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Educational influences on late-life health: Genetic propensity and attained education

Ericsson, M., Finch, B., Karlsson, I. K., Gatz, M., Reynolds, C. A., Pedersen, N. L., et al. (2024). Educational influences on late-life health: Genetic propensity and attained education. Journals of Gerontology: Series B, Psychological Sciences and Social Sciences, 79(1): gbad153. doi:10.1093/geronb/gbad153.

Item is

Files

show Files
hide Files
:
kog-23-mos-02-educational.pdf (Preprint), 760KB
Name:
kog-23-mos-02-educational.pdf
Description:
OA
OA-Status:
Hybrid
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
2023
Copyright Info:
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Locators

show

Creators

show
hide
 Creators:
Ericsson, Malin1, 2, Author
Finch, Brian3, Author
Karlsson, Ida K1, Author
Gatz, Margaret3, Author
Reynolds, Chandra A4, Author
Pedersen, Nancy L1, Author
Mosing, Miriam A.1, 5, Author                 
Affiliations:
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden , ou_persistent22              
2Aging Research Center, Karolinska Institutet & Stockholm University, Stockholm, Sweden, ou_persistent22              
3Center for Social and Economic Research, University of Southern California, Los Angeles, California, USA, ou_persistent22              
4Department of Psychology, University of California, Riverside, Riverside, California, USA, ou_persistent22              
5Department of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_3351901              

Content

show
hide
Free keywords: Educational attainment, genetics, twin studies, aging, gene-environment correlation
 Abstract: Objectives
The educational gradient in late-life health is well established. Despite this, there are still ambiguities concerning the role of underlying confounding by genetic influences and gene-environment (GE) interplay. Here we investigate the role of educational factors (attained and genetic propensities) on health and mortality in late life using genetic propensity for educational attainment (as measured by a genome-wide polygenic score, PGSEdu) and attained education.

Methods
By utilizing genetically informative twin data from the Swedish Twin Registry (n=14,570), we investigated influences of the educational measures, familial confounding as well as the possible presence of passive gene-environment correlation on both objective and subjective indicators of late-life health, i.e., the Frailty Index, Multimorbidity, Self-rated health, cardiovascular disease, and all-cause mortality.

Results
Using between-within models to adjust for shared familial factors, we found that the relationship between educational level and health and mortality later in life persisted despite controlling for familial confounding. PGSEdu and attained education both uniquely predicted late-life health and mortality, even when mutually adjusted. Between-within models of PGSEdu on the health outcomes in dizygotic twins, showed weak evidence for passive gene-environment correlation (prGE) in the education-health relationship.

Discussion
Both genetic propensity to education and attained education are (partly) independently associated with health in late life. These results lend further support for a causal education-health relationship but also raise the importance of genetic contributions and GE interplay.

Details

show
hide
Language(s): eng - English
 Dates: 2023-01-232023-10-202024-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/geronb/gbad153
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journals of Gerontology: Series B, Psychological Sciences and Social Sciences
  Other : Journal of Gerontology: Psychological Sciences
  Abbreviation : J Gerontol B Psychol Sci Soc Sci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Gerontological Society of America
Pages: - Volume / Issue: 79 (1) Sequence Number: gbad153 Start / End Page: - Identifier: ISSN: 1079-5014
CoNE: https://pure.mpg.de/cone/journals/resource/954926946763